Mechanistic insights into the interaction of cardiac sodium channel Na(v)1.5 with MOG1 and a new molecular mechanism for Brugada syndrome-MedSci.cn

Mechanistic insights into the interaction of cardiac sodium channel Na(v)1.5 with MOG1 and a new molecular mechanism for Brugada syndrome

Xiong, HB; Bai, XM; Quan, Z; Yu, D; Zhang, HF; Zhang, C; Liang, LN; Yao, YF; Yang, Q; Wang, ZJ; Wang, LF; Huang, Y; Li, H; Ren, X; Tu, X; Ke, T; Xu, CQ; Wang, QK

Ke, T; Xu, CQ; Wang, QK (通讯作者)，Coll Life Sci & Technol, Key Lab Mol Biophys MOE, Dept Biol Sci, Ctr Human Genome Res, Wuhan, Peoples R China.

HEART RHYTHM, 2022; 19 (3): 478

Abstract

BACKGROUND Mutations in cardiac sodium channel Na(v)1.5 cause Brugada syndrome (BrS). MOG1 is a chaperone that binds to Na(v)1.5, facilitates Na(v)1.5......

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Mechanistic insights into the interaction of cardiac sodium channel Na(v)1.5 with MOG1 and a new molecular mechanism for Brugada syndrome

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