The clinical application of SNP-based next-generation sequencing (SNP-NGS) for evaluation of chimerism and microchimerism after HLA-mismatched stem cell microtransplantation-MedSci.cn

The clinical application of SNP-based next-generation sequencing (SNP-NGS) for evaluation of chimerism and microchimerism after HLA-mismatched stem cell microtransplantation

Li, WY; Xu, Y; Feng, YF; Zhou, HX; Ma, X; Wu, DP; Chen, SN; Sun, AN

Chen, SN; Sun, AN (通讯作者)，Soochow Univ, Jiangsu Inst Hematol, Key Lab Thrombosis & Hemostasis, Minist Hlth,Affiliated Hosp 1, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China.;Chen, SN; Sun, AN (通讯作者)，Soochow Univ, Affiliated Hosp 1, Natl Clin Res Ctr Hematol Dis, Suzhou, Peoples R China.;Chen, SN; Sun, AN (通讯作者)，Soochow Univ, Collaborat Innovat Ctr Hematol, Inst Blood & Marrow Transplantat, Suzhou, Peoples R China.

Abstract

Genetic diagnostic methods for evaluation of chimerism after HSCT, such as STR-PCR and XY-FISH, have limited sensitivity. When donor chimerism is in t......

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The clinical application of SNP-based next-generation sequencing (SNP-NGS) for evaluation of chimerism and microchimerism after HLA-mismatched stem cell microtransplantation

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