Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants-MedSci.cn

Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants

Wu, LS; Hu, Y; Gane, EJ; Slaets, L; De Creus, A; Ding, YH; Niu, JQ; Schwabe, C; Goeyvaerts, N; Xu, ZN; Huo, DD; Tuefferd, M; Verbrugge, I; Van Remoortere, P; Schwertschlag, U; Vandenbossche, J

Vandenbossche, J (通讯作者)，Janssen Pharmaceut NV, Janssen Res & Dev, Beerse, Belgium.

Abstract

BackgroundJNJ-4964 is a TLR7 agonist, which, via a type I interferon (IFN)-dependent mechanism, may enhance host immunity suppressed by persistent exp......

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Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants

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