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Structure-activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease

Wu, CY; Zhang, GJ; Zhang, ZW; Jiang, X; Zhang, ZW; Li, HN; Qin, HL; Tang, WJ

Tang, WJ (corresponding author), Anhui Med Univ, Sch Pharm, Anhui Prov Key Lab Major Autoimmune Dis, Hefei 230032, Anhui, Peoples R China.; Qin, HL (corresponding author), Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021; 36 (1): 1860

Abstract

To discover novel scaffolds as leads against dementia, a series of delta-aryl-1,3-dienesulfonyl fluorides with alpha-halo, alpha-aryl and alpha-alkyny......

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