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Exploring effects of DNA methylation and gene expression on pan-cancer drug response by mathematical models

Lv, WH; Zhang, XD; Dong, HL; Wu, Q; Sun, BQ; Zhang, Y

Sun, BQ; Zhang, Y (corresponding author), Guangzhou Med Univ, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis, Guangzhou 51000, Peoples R China.

EXPERIMENTAL BIOLOGY AND MEDICINE, 2021; 246 (14): 1626

Abstract

Since genetic alteration only accounts for 20%-30% in the drug effect-related factors, the role of epigenetic regulation mechanisms in drug response i......

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