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Cryo-EM structure of the transposon-associated TnpB enzyme

Nakagawa, R; Hirano, H; Omura, SN; Nety, S; Kannan, S; Altae-Tran, H; Yao, X; Sakaguchi, Y; Ohira, T; Wu, WY; Nakayama, H; Shuto, Y; Tanaka, T; Sano, FK; Kusakizako, T; Kise, Y; Itoh, Y; Dohmae, N; van der Oost, J; Suzuki, T; Zhang, F; Nureki, O

Nureki, O (通讯作者)，Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo, Japan.;Nureki, O (通讯作者)，Univ Tokyo, Curreio, Tokyo, Japan.

NATURE, 2023; 616 (7956): 390

Abstract

The class 2 type V CRISPR effector Cas12 is thought to have evolved from the IS200/ IS605 superfamily of transposon-associated TnpB proteins1. Recent ......

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