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Gramine-based structure optimization to enhance anti-gastric cancer activity

Zhang, XH; Guo, Q; Wang, HY; Li, YH; Khamis, MY; Ma, LY; Wang, B; Liu, HM

Wang, B; Liu, HM (corresponding author), Zhengzhou Univ, Key Lab Henan Prov Drug Qual & Evaluat,, Key Lab Adv Drug Preparat Technol,Sch Pharmaceut, Minist Educ China,Collaborat Innovat Ctr New Drug, Zhengzhou 450001, Peoples R China.

BIOORGANIC CHEMISTRY, 2021; 107 ():

Abstract

Gramine is a natural indole alkaloid with a wide range of biological activities, but its anti-gastric cancer activity is poor. Herein, a pharmacophore......

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