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Preparation of (R)-3-aminopiperidine by resolution with optically active cyclic phosphoric acids

Sun, YJ; Hu, BB; Jing, YS; Wu, JL; Zhou, MC; Chen, M; Hao, FF; Zhang, C; Sun, FX

Sun, FX (corresponding author), Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, Shijiazhuang 050018, Hebei, Peoples R China.

CHIRALITY, 2021; 33 (7): 379

Abstract

(R)-3-aminopiperidine ((R)-APD), a key intermediate for alogliptin, trelagliptin, and linagliptin, was successfully resolved from racemic 3-aminopiper......

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