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Identification of unexpected unlabeled N,N-dimethylamide formation in the synthesis of deuterated fragment of ribociclib by a HATU-mediated coupling reaction

Gai, K; Liu, BM; Zhang, YS

Zhang, YS (reprint author), Chia Tai Tianqing Pharmaceut Grp Co LTD, Jiangsu Key Lab Targeted Antiviral Res, 699-8 Xuanwu Ave,Bldg 9, Nanjing 210023, Jiangsu, Peoples R China.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2019; 62 (2): 62

Abstract

Starting from N,N-dimethylamine and D2O, deuterated fragment of ribociclib was synthesized for use as a mass spectroscopy internal standard. Furthermo......

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