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"Photo-Rimonabant": Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar "Cis-On" CB1R Antagonist

Rodriguez-Soacha, DA; Fender, J; Ramirez, YA; Collado, JA; Munoz, E; Maitra, R; Sotriffer, C; Lorenz, K; Decker, M

Decker, M (corresponding author), Julius Maximilians Univ Wurzburg, Inst Pharmazie & Lebensmittelchem, Pharmazeut & Med Chem, D-97074 Wurzburg, Germany.

ACS CHEMICAL NEUROSCIENCE, 2021; 12 (9): 1632

Abstract

Human cannabinoid receptor type 1 (hCB(1)R) plays important roles in the regulation of appetite and development of addictive behaviors. Herein, we des......

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