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Improved process robustness, product quality and biological efficacy of an anti-CD52 monoclonal antibody upon pH shift in Chinese hamster ovary cell perfusion culture

Zheng, C; Zhuang, C; Chen, YT; Fu, Q; Qian, H; Wang, YC; Qin, JY; Wu, X; Qi, NM

Qi, NM (reprint author), Shanghai Jiao Tong Univ, Sch Pharm, Cell Culture & Bioproc Engn Lab, Dongchuan Rd 800, Shanghai 200240, Peoples R China.

PROCESS BIOCHEMISTRY, 2018; 65 (): 123

Abstract

pH is an important and commonly researched parameter that affects the production and quality of monoclonal antibodies (mAbs). Our previous study showe......

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