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Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano) phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site

Sun, M; Zhao, JX; Mao, Q; Yan, CD; Zhang, B; Yang, YW; Dai, XW; Gao, J; Lin, FW; Duan, YL; Zhang, TJ; Wang, SJ

Wang, SJ (corresponding author), Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drugs Design & Discovery, Minist Educ, 103 Culture Rd, Shenyang 110016, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2021; 38 ():

Abstract

Xanthine oxidase is the rate-limiting enzyme critical for the synthesis of uric acid, and therefore xanthine oxidase inhibitors are considered as one ......

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