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Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase

Ruf, S; Hallur, MS; Anchan, NK; Swamy, IN; Murugesan, KR; Sarkar, S; Narasimhulu, LK; Putta, VPRK; Shaik, S; Chandrasekar, DV; Mane, VS; Kadnur, SV; Suresh, J; Bhamidipati, RK; Singh, M; Burri, RR; Kristam, R; Schreuder, H; Czech, J; Rudolph, C; Mark

Ruf, S (reprint author), Sanofi Aventis Deutschland GmbH, Integrated Drug Discovery, D-65926 Frankfurt, Germany.; Rajagopal, S (reprint author), Jubilant Biosys Ltd, Dept Med Chem, Bangalore 560022, Karnataka, India.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018; 28 (5): 922

Abstract

Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that......

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