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Metabolic control of BRISC-SHMT2 assembly regulates immune signalling

Walden, M; Tian, L; Ross, RL; Sykora, UM; Byrne, DP; Hesketh, EL; Masandi, SK; Cassel, J; George, R; Ault, JR; El Oualid, F; Pawlowski, K; Salvino, JM; Eyers, PA; Ranson, NA; Del Galdo, F; Greenberg, RA; Zeqiraj, E

Zeqiraj, E (reprint author), Univ Leeds, Fac Biol Sci, Sch Mol & Cellular Biol, Astbury Ctr Struct Mol Biol, Leeds, W Yorkshire, England.; Greenberg, RA (reprint author), Univ Penn, Perelman Sch Med, Dept Canc Biol, Basser Ctr BRCA, Philadelphia, PA 19104

NATURE, 2019; 570 (7760): 194

Abstract

Serine hydroxymethyltransferase 2 (SHMT2) regulates one-carbon transfer reactions that are essential for amino acid and nucleotide metabolism, and use......

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