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《柳叶刀》首页头条刊发我国Hp疫苗重要研究成果

2015-07-03 佚名 健康报

Hp疫苗
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近日，国际顶尖学术期刊《柳叶刀》刊发第三军医大学药学系邹全明教授研究团队与中国食品药品检定研究院曾明研究员、江苏省疾病预防控制中心朱凤才教授团队合作完成的口服幽门螺杆菌疫苗III期临床研究成果。《柳叶刀》杂志官网在首页头条位置刊出该论文，并配发澳大利亚墨尔本大学Philip Sutton教授的专题评论，认为该疫苗的成功研制向预防幽门螺杆菌所致胃癌迈进了重要一步。 胃炎、胃溃疡、胃癌是严重危害人类

近日，国际顶尖学术期刊《柳叶刀》刊发第三军医大学药学系邹全明教授研究团队与中国食品药品检定研究院曾明研究员、江苏省疾病预防控制中心朱凤才教授团队合作完成的口服幽门螺杆菌疫苗III期临床研究成果。《柳叶刀》杂志官网在首页头条位置刊出该论文，并配发澳大利亚墨尔本大学Philip Sutton教授的专题评论，认为该疫苗的成功研制向预防幽门螺杆菌所致胃癌迈进了重要一步。

胃炎、胃溃疡、胃癌是严重危害人类健康的重大疾病，幽门螺杆菌(Hp)是胃病的最主要致病菌，世界卫生组织将其确定为胃癌第Ⅰ级致癌因子。我国Hp 感染率大于53%，慢性胃炎、胃及十二指肠溃疡患者超过2 亿人，2012 年治疗Hp所致疾病费用超过100 亿元。传统治疗一直依靠抗生素治疗Hp引发的相关疾病，但抗生素滥用导致Hp耐药菌不断产生。

邹全明研究团队着眼预防Hp感染性疾病的原创疫苗研究，在国际上率先创立了“分子内佐剂亚单位粘膜疫苗”设计原理及其关键技术，为粘膜感染病原体新型疫苗研究提供了全新的思路与借鉴，成功研发出具有完全自主知识产权的世界首个也是目前唯一获批的Hp疫苗，于2009年获批国家新药证书。该疫苗已获国际发明专利4项及国家发明专利12项，并获国家技术发明奖二等奖和重庆市技术发明奖一等奖。

此次疫苗III期临床研究通过对4464例6岁~15岁儿童随机进行双盲安慰剂对照试验，证明口服重组幽门螺杆菌疫苗具有良好的安全性和免疫原性。研究同时证明，Hp 疫苗能有效降低由该菌感染引起的胃炎、胃及十二指肠溃疡及胃癌发病率，既能从源头上控制其传播与感染，又能大幅减少防治费用。


 

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    2016-03-19 yangcristina

    真的很厉害

    0

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    2016-01-16 medsic

    嗯，

    0

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    2016-01-16 medsic

    嗯，

    0

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    2016-01-16 medsic

    不错！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=71602, encodeId=5dace1602c2, content=真的很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccc11622300, createdName=yangcristina, createdTime=Sat Mar 19 00:02:00 CST 2016, time=2016-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57828, encodeId=9d725e8280f, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57829, encodeId=03435e82922, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57830, encodeId=b1a05e8300f, content=不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57831, encodeId=e0415e831da, content=不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898385, encodeId=8f78189838538, content=<a href='/topic/show?id=0bdfe3394a4' target=_blank style='color:#2F92EE;'>#研究成果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73394, encryptionId=0bdfe3394a4, topicName=研究成果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Thu Aug 06 19:02:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32853, encodeId=30e23285372, content=强大，多创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Thu Jul 16 00:20:00 CST 2015, time=2015-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32131, encodeId=19cc32131ce, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 20:51:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30487, encodeId=36bb3048e8d, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:49:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30350, encodeId=5c2a3035026, content=太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Fri Jul 03 23:19:00 CST 2015, time=2015-07-03, status=1, ipAttribution=)]
    2016-01-16 medsic

    不错！

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=71602, encodeId=5dace1602c2, content=真的很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccc11622300, createdName=yangcristina, createdTime=Sat Mar 19 00:02:00 CST 2016, time=2016-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57828, encodeId=9d725e8280f, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57829, encodeId=03435e82922, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57830, encodeId=b1a05e8300f, content=不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57831, encodeId=e0415e831da, content=不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898385, encodeId=8f78189838538, content=<a href='/topic/show?id=0bdfe3394a4' target=_blank style='color:#2F92EE;'>#研究成果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73394, encryptionId=0bdfe3394a4, topicName=研究成果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Thu Aug 06 19:02:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32853, encodeId=30e23285372, content=强大，多创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Thu Jul 16 00:20:00 CST 2015, time=2015-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32131, encodeId=19cc32131ce, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 20:51:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30487, encodeId=36bb3048e8d, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:49:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30350, encodeId=5c2a3035026, content=太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Fri Jul 03 23:19:00 CST 2015, time=2015-07-03, status=1, ipAttribution=)]
    2015-08-06 xiongliangxl

    #研究成果#

    0

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    2015-07-16 lecoo

    强大，多创新

    0

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    2015-07-09 cmn

    加油

    0

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    2015-07-04 huaxipanxing

    牛

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=71602, encodeId=5dace1602c2, content=真的很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccc11622300, createdName=yangcristina, createdTime=Sat Mar 19 00:02:00 CST 2016, time=2016-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57828, encodeId=9d725e8280f, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57829, encodeId=03435e82922, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57830, encodeId=b1a05e8300f, content=不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57831, encodeId=e0415e831da, content=不错！, beContent=null, objectType=article, channel=null, level=null, likeNumber=207, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:43:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1898385, encodeId=8f78189838538, content=<a href='/topic/show?id=0bdfe3394a4' target=_blank style='color:#2F92EE;'>#研究成果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73394, encryptionId=0bdfe3394a4, topicName=研究成果)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=84fb152, createdName=xiongliangxl, createdTime=Thu Aug 06 19:02:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32853, encodeId=30e23285372, content=强大，多创新, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Thu Jul 16 00:20:00 CST 2015, time=2015-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32131, encodeId=19cc32131ce, content=加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 20:51:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30487, encodeId=36bb3048e8d, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=191, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:49:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30350, encodeId=5c2a3035026, content=太好了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Fri Jul 03 23:19:00 CST 2015, time=2015-07-03, status=1, ipAttribution=)]
    2015-07-03 caierhong

    太好了

    0

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