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EBioMed:饮酒是急性和慢性胰腺炎的风险因素

2015-11-30 MedSci MedSci原创

对于男性样本而言,酒精摄入量和患胰腺炎的风险的剂量-反应关系是单调的,饮酒与女性患急性胰腺炎的风险非线性相关。少量饮酒,酒精摄入量低于40 g /天与女性急性胰腺炎的风险降低相关。酒精摄入量超过100g/天,饮酒者患急性胰腺炎或慢性胰腺炎的风险均增加。

背景:胰腺炎是一种非常普遍的疾病,与一系列的胰腺内分泌和外分泌功能不足有关。虽然高酒精摄入量是胰腺炎的一个风险因素,目前尚没有系统的研究分析其与不同类型的胰腺炎的关系和导致胰腺炎发病的潜在的阈值。

方法:基于PRISMA指南进行系统的文献检索,研究酒精摄入量和胰腺炎之间的关系。非线性和线性随机效应剂量-反应meta分析,使用限制多元回归和分类meta分析。

结果:研究共纳入七项研究的157026例受试者和3618例胰腺炎患者。平均酒精摄入量和胰腺炎的剂量-反应关系的风险是单调的,证据显示饮酒与患慢性胰腺炎、男性饮酒者患急性胰腺炎的风险无非线性相关性,饮酒与女性患急性胰腺炎的风险非线性相关。

与不饮酒的人相比,每日少量饮酒,酒精摄入量<40g/天的女性受试者患急性胰腺炎的风险显著降低(RR 0.76,95%CI 0.60-0.97)。在男性样本中没有发现少量饮酒降低急性胰腺炎发病风险(RR 1.1,95%CI 0.69-1.74)。

饮酒者每日酒精摄入量100g/天,患胰腺炎风险增加(RR 6.29,95%CI 3.04-13.02)。

结论:对于男性样本而言,酒精摄入量和患胰腺炎的风险的剂量-反应关系是单调的,饮酒与女性患急性胰腺炎的风险非线性相关。少量饮酒,酒精摄入量低于40
g /天与女性急性胰腺炎的风险降低相关。酒精摄入量超过100g/天,饮酒者患急性胰腺炎或慢性胰腺炎的风险均增加。

资金:美国国家酒精滥用与酒精中毒研究所提供资助,基金号 R21AA023521。

原文出处:

Samokhvalov,Andriy V, et al. Alcohol Consumption as a Risk Factor for Acute and Chronic Pancreatitis: A Systematic Review and a Series of Meta-analyses. EBioMedicine. Published Online November 25,2015.


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    2016-02-12 sunylz
  2. [GetPortalCommentsPageByObjectIdResponse(id=1917226, encodeId=9631191e2261e, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Feb 12 15:54:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997076, encodeId=9b97199e07656, content=<a href='/topic/show?id=9221645e6f' target=_blank style='color:#2F92EE;'>#EBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6457, encryptionId=9221645e6f, topicName=EBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 01 11:54:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50228, encodeId=69db50228f8, content=以后少喝点, beContent=null, objectType=article, channel=null, level=null, likeNumber=242, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:39:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46917, encodeId=ed414691e9c, content=值得重视!尤其是西北好酒的人比较多!, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon Dec 21 01:53:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606742, encodeId=10f91606e427a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 02 11:54:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44257, encodeId=f65e4425e61, content=好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Dec 01 13:20:00 CST 2015, time=2015-12-01, status=1, ipAttribution=)]
    2016-02-01 linagood
  3. [GetPortalCommentsPageByObjectIdResponse(id=1917226, encodeId=9631191e2261e, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Feb 12 15:54:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997076, encodeId=9b97199e07656, content=<a href='/topic/show?id=9221645e6f' target=_blank style='color:#2F92EE;'>#EBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6457, encryptionId=9221645e6f, topicName=EBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Feb 01 11:54:00 CST 2016, time=2016-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50228, encodeId=69db50228f8, content=以后少喝点, beContent=null, objectType=article, channel=null, level=null, likeNumber=242, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:39:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=46917, encodeId=ed414691e9c, content=值得重视!尤其是西北好酒的人比较多!, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Mon Dec 21 01:53:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606742, encodeId=10f91606e427a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 02 11:54:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44257, encodeId=f65e4425e61, content=好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Tue Dec 01 13:20:00 CST 2015, time=2015-12-01, status=1, ipAttribution=)]
    2015-12-29 xyfg98

    以后少喝点

    0

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    2015-12-21 dhzzm

    值得重视!尤其是西北好酒的人比较多!

    0

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    2015-12-01 三三五五

    好棒

    0

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近日,一项发表于国际杂志Clinical and Translational Gastroenterology上的研究论文中,来自匹兹堡大学的研究人员通过研究发现,遗传突变、吸烟以及饮酒可相互作用共同增加个体患慢性胰腺炎的风险,相关研究或可揭示为何某些个体会患慢性胰腺炎,而单独的重度吸烟或重度饮酒者却并无疾病表现。 研究者David Whitcomb解释道,疾病的发病过程开始于急性胰腺炎,炎性症

PLoS Gene:研究表明囊性纤维化是两种类型疾病

一项由美国匹兹堡大学医学院多中心团队完成的新研究提示:囊性纤维化(CF)其实是两种不同的疾病,一种影响多个器官包括肺,一种不影响肺。这项研究发表在 PLOS Genetics杂志上,揭示了与囊性纤维化相关基因变异中的9个可导致胰腺炎,鼻窦炎和男性不育症,但却不对肺部造成伤害。 CF患者继承分别来自父母各方的CFTR基因的一个严重突变拷贝,CFTR生成那些构成通道来转运氯化物分子进出细胞的蛋白质,

AJOG:孕期胰腺炎,警惕子痫前期

目前关于妊娠期胰腺炎的发生率情况并没有较官方的统计或数据,根据不同地区的研究报道,该数据大概在1/1000~1/12000范围内。同时有研究报道孕期胰腺炎会增加20%的孕妇死亡率以及高达50%的胎儿死亡率;不过有新近的研究表明,死亡率风险并没有那么高,母胎死亡率数据分别为<1%和<5%。孕期胰腺炎的发作与普通人群胰腺炎发作病因类似,胆道疾病、饮酒、高脂饮食等。尽管胰腺炎在孕妇中发病率低,不过该疾病

胰腺炎发生的始作俑者

瑞典隆德大学的研究人员可能发现了民众患急性胰腺炎的原因及病情转归。研究结果对急性胰腺炎药物的研发和选择具有重要的借鉴作用。 大家都知道,若中性粒细胞被过度激活,则会引起胰腺出现炎症反应。然而,直到现在,是什么原因导致中性粒细胞出现激活还没有一个令人满意答案。因此,隆德大学的三个研究小组同时开始研究,以寻找到令人满意的答案。 隆德大学的Henrik Thorlacius教授说道:“我们的研究表明,中

CMAJ:绝经后激素替代治疗可增加胰腺炎风险

多篇病例报告表明,女性使用外源性性激素治疗可能会增加急性胰腺炎风险;然而,相关的流行病学数据不够充分。 为此,来自瑞典乌普萨拉大学Sörmlan临床研究中心的Oskarsson教授及其团队进行了一项研究,探讨女性绝经后激素替代治疗与急性胰腺炎风险之间的关系。该研究结果发表在03月18日的Canadian Medical Association journal杂志上。 该研究是一项基于人群的前瞻

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