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Immun Inflamm Dis:DENV特异性T细胞的功能表型与登革热的严重程度有关

2020-07-26 MedSci原创 MedSci原创

尽管登革病毒(DENV)特异性T细胞在急性登革热感染发病机制中的作用逐渐明了,但与较轻的临床疾病相关的病毒特异性T细胞的功能尚未清楚。本研究旨在探究DENV-NS3和DENV-NS5蛋白特异性T细胞在

尽管登革病毒(DENV)特异性T细胞在急性登革热感染发病机制中的作用逐渐明了,但与较轻的临床疾病相关的病毒特异性T细胞的功能尚未清楚。本研究旨在探究DENV-NS3和DENV-NS5蛋白特异性T细胞在登革热(DF)和登革出血热(DHF)患者中的功能有何不同。

 

使用细胞内细胞因子检测,我们评估了急性DF(n = 21)和DHF(n = 22)成年患者中干扰素γ(IFNγ)、肿瘤坏死因子-α(TNF-α)、巨噬细胞炎症蛋白-1β(MIP-1β)的产生和CD107a的表达。

 

结果显示,与DHF患者相比,DF患者中产生四种细胞因子、多功能DENV-NS3-和DENV-NS5特异性T细胞的频率更高。DF患者的DENV-NS3-和DENV-NS5特异性T细胞表达IFNγ > TNF-α > MIP-β > CD107a,而DHF患者的T细胞主要表达CD107a > MIP-1β > IFNγ > TNF-α。在DF患者中,DENV-NS3-和DENV-NS5特异性T细胞整体产生IFNγ或TNF-α的数量明显增多。DF(78.6%)和DHF(68.9%)患者的大多数NS3特异性T细胞是单一细胞因子的产生者;DF患者中76.6%的DENV-NS5特异性T细胞和DHF患者中77.1%的T细胞只产生单一细胞因子。然而,没有发现与多功能T细胞反应和病毒血症程度有显著关联。

 

总之,该结果表明,DENV特异性T细胞的功能表型很可能与临床疾病严重程度有关。

 

原始出处:

 

Dulharie T WijeratneSamitha Fernando, et al., Association of dengue virus-specific polyfunctional T-cell responses with clinical disease severity in acute dengue infection. Immun Inflamm Dis. 2019 Dec;7(4):276-285. doi: 10.1002/iid3.271. 

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    2020-10-25 lxg951
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    2020-07-28 xiaoyeshuang
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    2020-07-28 tastas
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    2020-07-26 关公面前耍柳叶刀

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