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NEJM:亚洲和拉丁美洲10个国家的儿童登革热状况

2016-03-26 MedSci MedSci原创

2个登革热疫苗有效性的3期试验中,对照组包括在登革热感染后两个大型的地区队列。这些队列提供了东南亚和拉丁美洲10个国家的有症状的儿童登革热的流行病学分析。

2个登革热疫苗有效性的3期试验中,对照组包括在登革热感染后两个大型的地区队列。这些队列提供了东南亚和拉丁美洲10个国家的有症状的儿童登革热的流行病学分析。

我们监测2011年1月到2013年12月,亚洲(印度尼西亚、马来西亚、菲律宾、泰国和越南)的3424名健康儿童(2-16岁)的急性发热性疾病和病毒学证实(VCD)的登革热,以及2011年2月到2014年4月拉丁美洲(巴西、哥伦比亚、洪都拉斯、墨西哥和波多黎各)6939名儿童(9-18岁)。急性发热通过非结构蛋白1抗原免疫测定和逆转录聚合酶链式反应确定为登革热。登革热出血热根据1997年WHO制定的标准。

每个队列中大约有10%的发热被证实为VCD,亚洲队列有319例VCD发作(4.6次发作每100人-年),拉丁美洲队列有389例VCD发作(2.9次每100人-年),围观察到年龄组趋势。每个队列发生登革热出血热均小于0.3次/100人-年。VCD发作需要住院的比例,亚洲队列19.1% ,拉丁美洲队列11.1%。在相似的年龄组(9-12岁和13-16岁),亚洲的登革热负担高于拉丁美洲。

登革热的负担在两个地区和所有年龄组都非常大。不同国家之间区别较大,但在亚洲国家的疾病发生率和严重程度要高于拉丁美洲国家。

原始出处:

Maïna L’Azou, Annick Moureau, Elsa Sarti,et al,Symptomatic Dengue in Children in 10 Asian and Latin American Countries,N Engl J Med 2016; 374:1155-1166March 24, 2016

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1635488, encodeId=a93816354884d, content=<a href='/topic/show?id=f3e256126b9' target=_blank style='color:#2F92EE;'>#拉丁美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56126, encryptionId=f3e256126b9, topicName=拉丁美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9e922479750, createdName=ms306040998833292, createdTime=Wed Nov 02 01:10:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746241, encodeId=7b821e462418b, content=<a href='/topic/show?id=0673e997283' target=_blank style='color:#2F92EE;'>#美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79972, encryptionId=0673e997283, topicName=美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c0735680798, createdName=kord1994, createdTime=Mon Oct 24 13:10:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74276, encodeId=0a52e42768a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74277, encodeId=f660e427761, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74278, encodeId=9da4e42788b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74093, encodeId=24bee40933f, content=我们国家还是很不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 28 09:24:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73992, encodeId=adcbe3992dc, content=亚洲登革热严重,还得寻找其原因!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun Mar 27 15:29:00 CST 2016, time=2016-03-27, status=1, ipAttribution=)]
    2016-10-24 kord1994
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    2016-03-28 忠诚向上

    好好学习一下

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1635488, encodeId=a93816354884d, content=<a href='/topic/show?id=f3e256126b9' target=_blank style='color:#2F92EE;'>#拉丁美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56126, encryptionId=f3e256126b9, topicName=拉丁美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9e922479750, createdName=ms306040998833292, createdTime=Wed Nov 02 01:10:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746241, encodeId=7b821e462418b, content=<a href='/topic/show?id=0673e997283' target=_blank style='color:#2F92EE;'>#美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79972, encryptionId=0673e997283, topicName=美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c0735680798, createdName=kord1994, createdTime=Mon Oct 24 13:10:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74276, encodeId=0a52e42768a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74277, encodeId=f660e427761, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74278, encodeId=9da4e42788b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74093, encodeId=24bee40933f, content=我们国家还是很不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 28 09:24:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73992, encodeId=adcbe3992dc, content=亚洲登革热严重,还得寻找其原因!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun Mar 27 15:29:00 CST 2016, time=2016-03-27, status=1, ipAttribution=)]
    2016-03-28 忠诚向上

    好好学习一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1635488, encodeId=a93816354884d, content=<a href='/topic/show?id=f3e256126b9' target=_blank style='color:#2F92EE;'>#拉丁美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56126, encryptionId=f3e256126b9, topicName=拉丁美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9e922479750, createdName=ms306040998833292, createdTime=Wed Nov 02 01:10:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746241, encodeId=7b821e462418b, content=<a href='/topic/show?id=0673e997283' target=_blank style='color:#2F92EE;'>#美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79972, encryptionId=0673e997283, topicName=美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c0735680798, createdName=kord1994, createdTime=Mon Oct 24 13:10:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74276, encodeId=0a52e42768a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74277, encodeId=f660e427761, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74278, encodeId=9da4e42788b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74093, encodeId=24bee40933f, content=我们国家还是很不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 28 09:24:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73992, encodeId=adcbe3992dc, content=亚洲登革热严重,还得寻找其原因!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun Mar 27 15:29:00 CST 2016, time=2016-03-27, status=1, ipAttribution=)]
    2016-03-28 忠诚向上

    好好学习一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1635488, encodeId=a93816354884d, content=<a href='/topic/show?id=f3e256126b9' target=_blank style='color:#2F92EE;'>#拉丁美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56126, encryptionId=f3e256126b9, topicName=拉丁美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9e922479750, createdName=ms306040998833292, createdTime=Wed Nov 02 01:10:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746241, encodeId=7b821e462418b, content=<a href='/topic/show?id=0673e997283' target=_blank style='color:#2F92EE;'>#美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79972, encryptionId=0673e997283, topicName=美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c0735680798, createdName=kord1994, createdTime=Mon Oct 24 13:10:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74276, encodeId=0a52e42768a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74277, encodeId=f660e427761, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74278, encodeId=9da4e42788b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74093, encodeId=24bee40933f, content=我们国家还是很不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 28 09:24:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73992, encodeId=adcbe3992dc, content=亚洲登革热严重,还得寻找其原因!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun Mar 27 15:29:00 CST 2016, time=2016-03-27, status=1, ipAttribution=)]
    2016-03-28 Gsurgeon

    我们国家还是很不错的

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1635488, encodeId=a93816354884d, content=<a href='/topic/show?id=f3e256126b9' target=_blank style='color:#2F92EE;'>#拉丁美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56126, encryptionId=f3e256126b9, topicName=拉丁美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9e922479750, createdName=ms306040998833292, createdTime=Wed Nov 02 01:10:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746241, encodeId=7b821e462418b, content=<a href='/topic/show?id=0673e997283' target=_blank style='color:#2F92EE;'>#美洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79972, encryptionId=0673e997283, topicName=美洲)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c0735680798, createdName=kord1994, createdTime=Mon Oct 24 13:10:00 CST 2016, time=2016-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74276, encodeId=0a52e42768a, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74277, encodeId=f660e427761, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74278, encodeId=9da4e42788b, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 28 23:39:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74093, encodeId=24bee40933f, content=我们国家还是很不错的, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 28 09:24:00 CST 2016, time=2016-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73992, encodeId=adcbe3992dc, content=亚洲登革热严重,还得寻找其原因!, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Sun Mar 27 15:29:00 CST 2016, time=2016-03-27, status=1, ipAttribution=)]
    2016-03-27 Lisa971

    亚洲登革热严重,还得寻找其原因!

    0

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