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J Gastroen Hepatol:脂肪摄入与溃疡性结肠炎

2017-08-08 zhangfan MedSci原创

荟萃研究认为,脂肪摄入与溃疡性结肠炎之间不存在显著的相关性,但该结论需要大规模临床研究的确证

脂肪摄入与溃疡性结肠炎之间的关系一直存在争议。近日研究人员对脂肪摄入与溃疡性结肠炎(UC)之间的关系进行了考察。这是一项荟萃研究,研究通过剂量反应荟萃分析定量评价脂肪摄入在UC发展中的作用。9项相关研究纳入本次荟萃分析,其中对照研究4起,前瞻研究5起,共包含966名溃疡性结肠炎患者以及171589名对照志愿者。研究发现,脂肪摄入与UC风险不存在非线性剂量反应关系。总体而言,每天总脂肪摄入增加30g的UC相对风险增加1.023(95% CI: 0.963–1.087; I2=24%; n=6),饱和脂肪摄入增加风险为1.063 (95%CI: 0.845–1.337; I2=44.5%; n=4),单不饱和脂肪摄入增加风险为1.214 (95%CI: 0.911–1.618; I2=63.1%; n=4),多不饱和脂肪摄入增加风险为1.247 (95%CI: 0.948–1.640; I2=25.4%; n=4)。亚组以及敏感性分析表明,在调整吸烟状态后,多不饱和脂肪摄入与溃疡性结肠炎弱相关(RR: 1.617, 95%CI: 1.045–2.502; I2=0%; n=3)。对于多不饱

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1711162, encodeId=db531e11162b6, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Wed Dec 06 13:22:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071876, encodeId=7adf20e187661, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Mar 02 19:22:00 CST 2018, time=2018-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694996, encodeId=e15a169499691, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Sat Jun 23 14:22:00 CST 2018, time=2018-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426792, encodeId=a6181426e92b4, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Aug 10 01:22:00 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596764, encodeId=756a1596e6476, content=<a href='/topic/show?id=90e98435334' target=_blank style='color:#2F92EE;'>#脂肪摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84353, encryptionId=90e98435334, topicName=脂肪摄入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=406418414194, createdName=wumeihua94, createdTime=Thu Aug 10 01:22:00 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231436, encodeId=2c822314369c, content=荟萃研究认为,脂肪摄入与溃疡性结肠炎之间不存在显著的相关性,但该结论需要大规模临床研究的确证。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Tue Aug 08 10:59:41 CST 2017, time=2017-08-08, status=1, ipAttribution=)]
    2018-03-02 许安
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    2018-06-23 nymo
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    2017-08-10 gwc384
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    2017-08-08 Julie W

    荟萃研究认为,脂肪摄入与溃疡性结肠炎之间不存在显著的相关性,但该结论需要大规模临床研究的确证。

    0

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