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Diabetes Care:儿童体重指数是1型糖尿病进展的危险因素吗?

2017-02-16 xing.T MedSci原创

由此可见,升高的BMI与小儿自身抗体阳性亲属糖尿病进展的风险增加相关,但受性别和年龄的影响而有所差异。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章。研究人员旨在评价随着时间的推移逐渐增加的BMI对青少年1型糖尿病进展的影响。

研究人员重点分析了1117名儿童的数据,这些儿童来自于TrialNet预防途径队列(1型糖尿病患者自身抗体阳性的亲戚)。研究人员通过纵向累积经年龄和性别调整后BMI在第八十五位百分位数以上来得出一个累积过量BMI指数(ceBMI)。递归分割和多变量分析得出年龄和性别特异性ceBMI阈值来检测最大1型糖尿病风险个体。

研究人员发现更高的ceBMI可以显著增加1型糖尿病的进展风险。相比于年龄超过12岁和男性儿童中,年龄小于12岁的较低ceBMI 值的女性儿童其糖尿病发生风险增加。

由此可见,升高的BMI与小儿自身抗体阳性亲属糖尿病进展的风险增加相关,但受性别和年龄的影响而有所差异。

原始出处:

Christine Therese Ferrara, et al. Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development. Diabetes Care 2017 Feb; dc162331. https://doi.org/10.2337/dc16-2331

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