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Respir Res:哪种BDR预测严重COPD患者的急性加重风险更准确?

2017-08-22 徐晓涵,石岩 环球医学

2017年5月,发表在《Respir Res》的一项由韩国科学家进行的logistic回归分析,评估了哪种支气管舒张可逆(BDR)标准可预测严重COPD中严重AE患者。

慢性阻塞性肺病(COPD)是一种与临床不良临床结局相关的疾病,包括肺功能衰退和急性加重(AE)。COPD的发病率和死亡率已出现全球增长趋势,所以进一步研究这种疾病的特征和管理很有必要。2017年5月,发表在《Respir Res》的一项由韩国科学家进行的logistic回归分析,评估了哪种支气管舒张可逆(BDR)标准可预测严重COPD中严重AE患者。

背景:尚不清楚各种BDR标准是否会影响COPD的预后。本项研究的目的是评估根据各种BDR标准定义的阳性BDR对COPD患者严重AE风险的影响。

方法:本项研究纳入经过至少1年随访的韩国4个前瞻性COPD队列的患者。评估的BDR标准包括慢性阻塞性肺疾病全球倡议(GOLD)、美国胸科协会(ATS)、美国胸科医师协会(ACCP)、哮喘-COPD重叠综合征(ACOS)西班牙定义的主要标准、全球哮喘防治倡议(GINA)中与ACOS相容的标准和欧洲呼吸协会(ERS)。使用logistic回归模型分析1年内需要住院的严重AE患者的比率,根据每套标准确定BDR结果。

结果:在总共854名患者中,BDR阳性病例根据所使用的标准变化。根据GINA,BDR阳性率为3.5%;根据ATS标准为29.9%。根据GOLD标准的阳性BDR与严重AE风险的降低显著相关[调整后的比值比(aOR)=0.38;95%置信区间(CI)=0.15~0.93]。即使在仅包括吸烟史至少10包-年的患者的敏感性分析中和倾向评分匹配的参与者的分析中,这一结果仍具有统计学显著意义。

结论:在阳性BDR的不同标准中,GOLD的使用与COPD患者中严重AE风险的降低显著相关。增加ICS/LABA的使用可能会影响这种关系。

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    2018-04-14 871538379

    看来gold的标准还是在众标准中蛮有价值的

    0

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    2017-08-24 gous
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    2017-08-23 1e1850b7m51(暂无匿称)

    学习

    0

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    2017-08-23 130****4638

    学习了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=305611, encodeId=8ebf305611b6, content=看来gold的标准还是在众标准中蛮有价值的, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Sat Apr 14 06:45:10 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894391, encodeId=1e041894391f4, content=<a href='/topic/show?id=db705221569' target=_blank style='color:#2F92EE;'>#急性加重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52215, encryptionId=db705221569, topicName=急性加重)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2978132, createdName=minzju5052, createdTime=Fri Nov 17 06:14:00 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488803, encodeId=543e1488803cd, content=<a href='/topic/show?id=69675090ca' target=_blank style='color:#2F92EE;'>#COPD患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5090, encryptionId=69675090ca, topicName=COPD患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=852e8475198, createdName=gous, createdTime=Thu Aug 24 07:14:00 CST 2017, time=2017-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236257, encodeId=403723625e08, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuPDT72UPNq0kdsAuyEGdV6icnshFTGeRRbVcyaUp1tU2dM5oJaAPDzZ8Wzd5pz50OhAwiaCIjYFYQN/0, createdBy=d6121981845, createdName=1e1850b7m51(暂无匿称), createdTime=Wed Aug 23 07:13:24 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236199, encodeId=d97823619947, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Wed Aug 23 06:46:31 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236054, encodeId=1a21236054d1, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Tue Aug 22 16:58:06 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236053, encodeId=b158236053b7, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Aug 22 16:36:20 CST 2017, time=2017-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236048, encodeId=4f5923604840, content=学了........., beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Tue Aug 22 16:31:35 CST 2017, time=2017-08-22, status=1, ipAttribution=)]
    2017-08-22 中医痴

    不错的.学习了.谢谢分享!

    0

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    2017-08-22 wxl882001

    学习一下

    0

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    2017-08-22 135****7952平儿

    学了.........

    0

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