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BMJ:尼古丁贴片治疗可降低戒烟人群伐尼克兰使用量

2018-06-15 zhangfan MedSci原创

研究认为尼古丁贴片不能提高戒烟率,但可减少戒烟人群伐尼克兰的使用量

近日研究人员就尼古丁贴片的戒烟效果进行了考察。

总计1792名烟民参与研究,其中干预组899人,对照组893人,对照参与者接受标准戒烟药物治疗和行为支持,干预组在相同的标准治疗基础上,在戒烟药物开始前4周接受21mg尼古丁贴片治疗。研究的主要终点为6个月生化验证戒断率,次要终点包括4周及12个月戒断率。

干预组157人(17.5%)以及对照组129人(14.4%)实现6个月戒断,组间差异为3%,贴片干预效果的比值比为1.25;但组间戒烟治疗中伐尼克兰的使用频率差异显著,调整后贴片干预效果的比值比上升为1.34,组间差异为3.8%。治疗后4周,贴片干预效果的比值比为1.21,组间戒断率差异为4.3%,伐尼克兰使用频率调整后比值比为1.32。12个月贴片干预效果的比值比为1.28,组间戒断率差异为2.7%,伐尼克兰使用频率调整后比值比为1.36。5.9%的贴片组参与者因耐受性停止治疗,贴片组恶心等肠胃症状率较对照组增加4.0%。干预组以及对照组分别发生8例严重不良事件。

研究认为尼古丁贴片不能提高戒烟率,但可减少戒烟人群伐尼克兰的使用量。

原始出处:


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    2019-04-24 gaoxiaoe
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    2018-06-15 happsf

    学习

    0

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    2018-06-15 lietome2

    好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

    0

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