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JAHA:高血压与微量白蛋白尿的双向和时间关联

2018-11-14 xing.T MedSci原创

由此可见,这些发现表明中国成年人微量白蛋白尿与高血压之间存在显著的双向关联。尿白蛋白排泄增加更可能发生在高血压发生之前。微量白蛋白尿与高血压之间的因果关系需要进一步研究。

虽然高血压和微量白蛋白尿密切相关,但高血压和微量白蛋白尿之间双向关联的程度和时间顺序在很大程度上是未知的。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员的目的是描绘高血压与微量白蛋白尿之间的双向和时间关系。

研究人员利用4年测量两次血压和尿白蛋白的中国成人纵向队列,并通过双向和交叉滞后分析评估了高血压与微量白蛋白尿之间的时间关联。所有参与者在基线时均无血管疾病和慢性肾病。

双向关联分析发现,基线时微量白蛋白尿可预测高血压事件发生的风险(比值比=1.75,P=0.028),基线血压也能预测微量白蛋白尿的风险(收缩压和舒张压每升高一个SD的比值比分别为1.27和1.21;所有P<0.05)。交叉滞后分析显示基线收缩压与随访时的尿白蛋白显著相关(P=0.079),这显著性弱于基线尿白蛋白与随访血压之间的关系(P<0.001)。

由此可见,这些发现表明中国成年人微量白蛋白尿与高血压之间存在显著的双向关联。尿白蛋白排泄增加更可能发生在高血压发生之前。微量白蛋白尿与高血压之间的因果关系需要进一步研究。

原始出处:

Mingzhi Zhang.et al.Bidirectional and Temporal Association Between Hypertension and Microalbuminuria: A Longitudinal Study in Chinese Adults.JAHA.2018. https://www.ahajournals.org/doi/10.1161/JAHA.118.010723

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    2018-11-16 zhaohui6731
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    2018-11-14 医者仁心5538

    学习了

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    2018-11-14 衣带渐宽

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