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JCI:脂肪组织对胰岛素过于敏感竟会导致肥胖!

2016-06-23 MedSci MedSci原创

最近一项研究发现SORLA是影响脂肪组织代谢平衡的一个蛋白分子,该分子表达过多会使脂肪细胞对胰岛素过度敏感,导致脂肪细胞脂解活性下降。SORLA参与细胞内蛋白质的分选加工过程,之前对SORLA分子的研究主要集中于阿尔茨海默病领域,研究发现SORLA能够通过降低蛋白水平抑制危险性蛋白沉积的形成,但是该分子在脂肪组织中发挥着另外一种作用:使脂肪组织对胰岛素过度敏感,导致脂肪过度沉积。来自德国的研究人员

最近一项研究发现SORLA是影响脂肪组织代谢平衡的一个蛋白分子,该分子表达过多会使脂肪细胞对胰岛素过度敏感,导致脂肪细胞脂解活性下降。

SORLA参与细胞内蛋白质的分选加工过程,之前对SORLA分子的研究主要集中于阿尔茨海默病领域,研究发现SORLA能够通过降低蛋白水平抑制危险性蛋白沉积的形成,但是该分子在脂肪组织中发挥着另外一种作用:使脂肪组织对胰岛素过度敏感,导致脂肪过度沉积。

来自德国的研究人员对SORLA在脂肪组织中的功能进行了更加细致的研究,相关研究结果发表在国际学术期刊The Journal of Clinical Investigation上。

研究人员首先对362个超重个体的脂肪组织进行了分析,他们发现脂肪组织中SORLA表达越多,人就会越胖。随后他们建立了脂肪组织内特异性过表达SORLA的小鼠模型,并进行高脂饮食喂养,这些小鼠很快就出现肥胖状态,与之相比在进食量相同的情况下抑制SORLA基因表达会导致小鼠抵抗饮食诱导的肥胖。

研究发现过表达SORLA会使细胞对胰岛素的敏感性变得更强。这主要是由于SORLA能够对需要进行回收的胰岛素受体进行标记防止胰岛素受体进入溶酶体发生降解。SORLA表达水平越高,到达细胞表面的胰岛素受体就会越多,而胰岛素受体的数量决定了结合到细胞上的胰岛素分子数量,从而导致细胞对胰岛素过于敏感抑制了脂肪细胞的脂解过程。

研究人员表示2型糖尿病不仅包括胰岛素抵抗的问题,脂肪组织对胰岛素过于敏感也会导致代谢异常,因此这项研究为肥胖,糖尿病以及相关代谢紊乱的治疗提供了新的方向。除此之外研究还发现在正常饮食情况下SORLA表达水平并不会对体重造成影响,只有在高脂这种不健康饮食情况下,SORLA才会导致体重出现极度增加,这表明如果你的饮食不健康,脂肪组织对胰岛素过度敏感就会变成一个影响代谢健康的危险因素。

原始出处

Vanessa Schmidt,1 Nadja Schulz,2,3 Xin Yan,SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.JCI.2016

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    2016-12-19 baoya
  3. [GetPortalCommentsPageByObjectIdResponse(id=1982028, encodeId=b287198202860, content=<a href='/topic/show?id=12c010266f0' target=_blank style='color:#2F92EE;'>#JCI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10266, encryptionId=12c010266f0, topicName=JCI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e30378, createdName=caobinglei8079, createdTime=Fri Dec 23 22:01:00 CST 2016, time=2016-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749617, encodeId=f77f1e49617b4, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 19 00:01:00 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=132091, encodeId=803f1320911b, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Sep 21 08:24:00 CST 2016, time=2016-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125769, encodeId=ff72125e69bb, content=什么事物都是平衡了最好,不能矫枉过正,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 21:56:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345732, encodeId=c2861345e32fe, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Sat Jun 25 14:01:00 CST 2016, time=2016-06-25, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-13 舒心和人

    什么事物都是平衡了最好,不能矫枉过正,感谢分享

    0

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