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J Clin Endocrinol Metab:口服避孕药会不会降低性功能?

2016-08-25 Moon 译 MedSci原创

口服避孕药是最常见的药物类避孕方法,由人工合成的雌激素和孕激素配制成的,避孕的成功率极高。不过口服避孕药对性功能是否会产生影响?研究者进行了一项双盲、随机、安慰剂对照试验,探究口服避孕药是否会对性行为产生因果关系的影响,并假设广泛使用药物会损害性行为。研究纳入了340名健康妇女,年龄在18-35岁,随机分为口服避孕药组(150 μg左炔诺孕酮+30 μg乙炔雌二醇)和安慰剂组,持续3个月;最终33

口服避孕药是最常见的药物类避孕方法,口服避孕药由人工合成的雌激素和孕激素配制成的,避孕的成功率极高。不过口服避孕药对性功能是否会产生影响?

研究者进行了一项双盲、随机、安慰剂对照试验,探究口服避孕药是否会对性行为产生因果关系的影响,并假设广泛使用药物会损害性行为。

研究纳入了340名健康妇女,年龄在18-35岁,随机分为口服避孕药组(150 μg左炔诺孕酮+30 μg乙炔雌二醇)和安慰剂组,持续3个月;最终332名参与者完成了研究。

主要结果是女性性功能状况(PFSF)的总评分。次要结果为PFSF中的七个领域、性活动日志以及个人困扰量表。

结果显示,口服避孕药组和安慰剂组女性的整体性功能是相似的。不过与安慰剂组相比,口服避孕药组以下方面显著降低:PFSF中的性欲望(-4.4, 95% CI, -8.49- -0.38, P = .032)、性唤起(-5.1, 95% CI, -9.63- -0.48, P = .030)和性愉悦(-5.1, 95% CI, -9.97- -0.32, P = .036)。性高潮、关注、响应能力和自我形象在两组间相似。性快感或对性满意的平均频率和个人苦恼在两组间相似。

这项研究显示,虽然口服含左炔诺孕酮的避孕药会对性功能领域的三个方面产生不利影响,但是对于女性整体性功能没有负面影响。

原始出处:

Zethraeus N.et al.Combined Oral Contraceptives and Sexual Function in Women - a Double-Blind, Randomized, Placebo-Controlled Trial.J Clin Endocrinol Metab. 2016 Aug 15:jc20162032. [Epub ahead of print]


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    2016-08-27 仁医06
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    2016-09-13 guojianrong
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    2016-09-26 ylzr123

    好文,从这里学习了好多新知识,新信息。赞了!

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115733, encodeId=c1ef115e3386, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115732, encodeId=fc26115e32cc, content=不错的知识点学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115733, encodeId=c1ef115e3386, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115732, encodeId=fc26115e32cc, content=不错的知识点学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-12 舒心和人

    虽然对生育能力没有影响,但是也要避免经常服用,扰乱体内激素的正常分泌还会带来其他困扰

    0

  6. 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likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-09 1e0d5b16m97(暂无匿称)

    不错的知识点学到了很多。

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:11:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123940, encodeId=90ff123940c1, content=虽然对生育能力没有影响,但是也要避免经常服用,扰乱体内激素的正常分泌还会带来其他困扰, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon Sep 12 19:45:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115739, encodeId=5bcc115e3974, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115738, encodeId=11bc115e3840, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115731, encodeId=d022115e3123, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115733, encodeId=c1ef115e3386, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115732, encodeId=fc26115e32cc, content=不错的知识点学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-09 1e0d5b16m97(暂无匿称)

    不错的知识点学到了很多。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1895954, encodeId=26df18959545e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Aug 27 13:35:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887568, encodeId=932e188e568aa, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Sep 13 15:35:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135260, encodeId=249d135260e8, content=好文,从这里学习了好多新知识,新信息。赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 26 07:05:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131634, encodeId=200b13163468, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:11:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123940, encodeId=90ff123940c1, content=虽然对生育能力没有影响,但是也要避免经常服用,扰乱体内激素的正常分泌还会带来其他困扰, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon Sep 12 19:45:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115739, encodeId=5bcc115e3974, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115738, encodeId=11bc115e3840, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115731, encodeId=d022115e3123, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115733, encodeId=c1ef115e3386, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115732, encodeId=fc26115e32cc, content=不错的知识点学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-09 1e0d5b16m97(暂无匿称)

    不错的知识点学到了很多。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1895954, encodeId=26df18959545e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Aug 27 13:35:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887568, encodeId=932e188e568aa, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Sep 13 15:35:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135260, encodeId=249d135260e8, content=好文,从这里学习了好多新知识,新信息。赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 26 07:05:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131634, encodeId=200b13163468, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:11:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123940, encodeId=90ff123940c1, content=虽然对生育能力没有影响,但是也要避免经常服用,扰乱体内激素的正常分泌还会带来其他困扰, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon Sep 12 19:45:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115739, encodeId=5bcc115e3974, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115738, encodeId=11bc115e3840, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115731, encodeId=d022115e3123, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115733, encodeId=c1ef115e3386, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115732, encodeId=fc26115e32cc, content=不错的知识点学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-09 1e0d5b16m97(暂无匿称)

    不错的知识点学到了很多。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1895954, encodeId=26df18959545e, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Aug 27 13:35:00 CST 2016, time=2016-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887568, encodeId=932e188e568aa, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue Sep 13 15:35:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135260, encodeId=249d135260e8, content=好文,从这里学习了好多新知识,新信息。赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Sep 26 07:05:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131634, encodeId=200b13163468, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:11:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=123940, encodeId=90ff123940c1, content=虽然对生育能力没有影响,但是也要避免经常服用,扰乱体内激素的正常分泌还会带来其他困扰, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon Sep 12 19:45:00 CST 2016, time=2016-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115739, encodeId=5bcc115e3974, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115738, encodeId=11bc115e3840, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:25:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115731, encodeId=d022115e3123, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115733, encodeId=c1ef115e3386, content=不错的知识点学到了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=115732, encodeId=fc26115e32cc, content=不错的知识点学到了很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160820/IMG57B7D87F2AA596063.jpg, createdBy=c3e01933512, createdName=1e0d5b16m97(暂无匿称), createdTime=Fri Sep 09 16:24:00 CST 2016, time=2016-09-09, status=1, ipAttribution=)]
    2016-09-09 1e0d5b16m97(暂无匿称)

    不错的知识点学到了很多

    0

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JAMA Neurol:胖女人小心了,口服避孕药脑静脉血栓形成风险大

近期发表在JAMA Neurology的研究称,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,脑静脉血栓形成(CVT)的风险更大。CVT是一种罕见的疾病,主要影响年轻的成年人和儿童。CVT与静脉血栓栓塞症(VTE)有相同的危险因素如癌症和口服避孕药,此外CVT还有特定的危险因素如局部感染和头部外伤。荷兰阿姆斯特丹学术医疗中心的Jonathan M. Coutinho博士对来自两家医院的

BMJ: 口服避孕药的女性乳腺癌死亡率更高、卵巢癌死亡率更低

研究目的:研究口服避孕药的使用与全因死亡率和特定原因死亡率的关系。研究方法:在护理师健康研究(Nurses' Health Study)中,采用前瞻性群组研究设计,从1976-2012收集数据。对121701个参与者随访36年;从1976-1982年,每两年一次对参与者口服避孕药的使用情况进行记录。对随访期间的全因死亡率和特定原因死亡率进行评估。采用cox比例风险模型计算与口服避孕药相关的全因死亡

Fertil Steril:术后长期服用避孕药或孕激素是预防子宫内膜异位症术后复发的有效手段

    虽然手术切除子宫内膜异位症既改善疼痛,提高生育能力,复发可以进一步加剧疼痛和降低生育能力,这反过来又影响生活质量和增加个人和社会成本的。因此,防止术后复发是至关重要的。本文回顾了自20世纪90年代以来,预防子宫内膜异位症术后复发的证据。在过去的5年中,许多新的研究已经进行并表明,长期的术后药物治疗显著降低复发率。这些研究大多用循环或连续的治疗方案使用口服避孕药

BMJ:静脉血栓栓塞与复方口服避孕药的联系

    目的  调查使用复方口服避孕药和静脉血栓栓塞的风险之间的关联,也将孕激素的类型考虑在内。    设计  两个巢式病例对照研究。    设置  在英国,一般做法有助于临床实践研究数据链(CPRD;618次实践)和QResearch初级保健数据库(722次实践)研究。    参与者 &

J Thromb Heamost:口服避孕药、血栓与静脉血栓栓塞的风险:系统回顾和荟萃分析

根据一项荟萃分析的结果,严重的遗传性易栓症女性使用口服避孕药会增加静脉血栓栓塞(VTE)的风险。格罗宁根大学医学中心的Elizabeth F.W. van Vlijmen博士和他的同事利用MEDLINE和EMBASE数据库,对12项病例对照研究和3项队列研究的数据进行了分析,评估家庭中有轻度和重度的遗传性易栓症妇女使用复方口服避孕药后的首次VTE的额外风险。研究人员定义为轻度血栓形成倾向为因子V

J Clin Endocrinol Metab:自发性卵巢早衰的女性,联合激素替代疗法较口服避孕药可更好的提高腰椎的骨密度

卵巢早衰(POF)的女性通常存在长时间的雌激素缺乏,导致的其中一个主要后果是骨丧失。目前最佳的雌激素替代疗法尚未可知,且其管理也并未有研究支持。联合激素替代疗法(HRT)或联合口服避孕药(COCP)是其中的两大重要的治疗方法。本研究旨在比较对自发性POF女性经HRT或COCP治疗后的骨密度和骨转换的效果,并观察未经治疗的结果。采用开放随机试验设计,为期两年,对比HRT和COCP治疗的效果,并采用非

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