Baidu
map

口腔科

订阅

MedSci主页 / 所有栏目 / 口腔科

J Periodontol：牙周病者唾液集落刺激因子和白介素-34水平

2017-08-17 MedSci MedSci原创

牙周炎牙龈炎细胞间信号肽类和蛋白质唾液
关注

集落刺激因子（CSF）-1和白介素（IL）-34是巨噬细胞生长因子和破骨细胞发生的调节因子。他们是否参与牙周病还不得而知。本研究的目的是探讨牙周病者唾液中CSF-1和IL-34的存在。

集落刺激因子（CSF）-1和白介素（IL）-34是巨噬细胞生长因子和破骨细胞发生的调节因子。他们是否参与牙周病还不得而知。本研究的目的是探讨牙周病者唾液中CSF-1和IL-34的存在。

通过酶联免疫吸附法测定健康供体唾液（n = 21）。在48例患者（29例牙周炎患者，12例牙龈炎患者和7例健康患者）中确定了唾液CSF-1，IL-34和基质金属蛋白酶（MMP）-8（牙周炎的一种生物标志物候选），并与以下临床相关牙周参数：探诊出血，探诊深度，临床附着丧失和菌斑指数关联。另外分组的牙龈炎患者（n = 21）和一些牙周炎患者（n = 11）进行非手术牙周治疗，随后测试唾液CSF-1，IL-34和MMP-8的变化水平确定，与牙周结果相关。

结果：与健康患者相比，牙周炎患者的唾液中CSF-1和MMP-8水平升高，IL-34水平较低，牙周炎患者观察到较高的CSF-1 / IL-34比例。在牙龈炎和牙周炎患者中，CSF-1与MMP-8呈正相关，两者与IL-34呈负相关。牙周炎患者临床牙周参数与CSF-1，MMP-8和CSF-1 / IL-34比值呈正相关，与IL-34呈负相关。治疗后，牙龈炎患者CSF-1和MMP-8水平降低，临床指标改善。

结论：CSF-1和IL-34存在于唾液中，似乎在牙周病中具有互补作用：稳态中的IL-34和炎症中的CSF-1。

原始出处：

G.L. Martinez， M. Majster， N. Bjurshammar， et al. Salivary Colony Stimulating Factor-1 and Interleukin-34 in Periodontal Disease. Journal of periodontal research. 2017 August. doi： 10.1902/ jop.2017.160815

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1726662, encodeId=c94a1e26662a8, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Oct 15 09:59:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282254, encodeId=bcff1282254b1, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372103, encodeId=ff4713e210307, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450604, encodeId=38f3145060453, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-10-15 feather89

    #PE#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1726662, encodeId=c94a1e26662a8, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Oct 15 09:59:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282254, encodeId=bcff1282254b1, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372103, encodeId=ff4713e210307, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450604, encodeId=38f3145060453, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 linagood

    #牙周病#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1726662, encodeId=c94a1e26662a8, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Oct 15 09:59:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282254, encodeId=bcff1282254b1, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372103, encodeId=ff4713e210307, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450604, encodeId=38f3145060453, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 budeshao

    #白介素#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1726662, encodeId=c94a1e26662a8, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Oct 15 09:59:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282254, encodeId=bcff1282254b1, content=<a href='/topic/show?id=46a06e5220c' target=_blank style='color:#2F92EE;'>#牙周病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67522, encryptionId=46a06e5220c, topicName=牙周病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372103, encodeId=ff4713e210307, content=<a href='/topic/show?id=6ca1e1621c4' target=_blank style='color:#2F92EE;'>#白介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71621, encryptionId=6ca1e1621c4, topicName=白介素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0e95336, createdName=budeshao, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450604, encodeId=38f3145060453, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Sat Aug 19 04:59:00 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 liuyong2982

    #牙周#

    0

相关资讯

重度牙周炎诊断标准及特殊人群牙周病治疗原则的中国专家共识

近年来，广大临床医师对牙周病诊疗的重视程度日益增加，但在临床对牙周病的诊治工作中常面临一些困惑，缺乏获得具体指导的途径，这突显了对牙周病临床诊疗的循证需求。为此，中华口腔医学会牙周病学专业委员会组织专家，根据国内外现有循证医学证据和专家经验，在充分讨论的基础上制定了本共识，以期指导和帮助中国广大临床医师在牙周病的临床诊疗中做出更合理的诊疗决策。

J Periodontol：牙周炎与血管内皮功能障碍：牙周临床指标和唾液标记物白细胞介素-1β，肿瘤坏死因子-α，基质金属蛋白酶，金属蛋白酶复合物组织抑制剂和一

牙周炎与发生动脉粥样硬化性心血管疾病（ACD）的风险高度相关。内皮功能障碍（ED）是早期ACD的参数，迄今为止很少研究其与牙周炎的关系。本研究的目的是通过牙周临床参数和唾液标志物白细胞介素（IL）-1β，肿瘤坏死因子（TNF）-α，一氧化氮（NO）和基质金属蛋白酶（MMP）-2和金属蛋白酶组织抑制剂（TIMP）-2复合物来评估牙周炎和ED之间的关系。

J Clin Periodontol：牙周炎和非酒精性脂肪肝疾病的关系：一项基于人群的健康调查研究

非酒精性脂肪肝疾病(NAFLD)使20-30%的成年人承受着罹患慢性低度炎症的风险，如：肥胖和胰岛素抗药性。由于牙周炎可以引发低度炎症，研究者推测：牙周炎可能会促使NAFLD发生。为此，这项研究的目的是通过对波美拉尼亚地区2,623名参与者进行健康调查，分析牙周炎与NAFLD发生率之间的流行病学联系。

J Periodontol：同一的个体种植体与天然牙周围的生物标志物和细菌

该横断面研究评估了种植体周围龈沟液（PICF）/牙龈沟液（GCF）中的细胞因子水平以及来自同一人群临床健康或患病位点的龈下/粘膜下菌斑的选择。

J Periodontol：自体富血小板纤维蛋白膜在龈沟液中生长因子水平与牙周愈合中的优势

本研究评估血小板富集纤维蛋白（PRF）与常规瓣膜手术联合对龈沟液（GCF）和牙周愈合中生长因子水平的影响。

J Periodontol：白藜芦醇对于香烟烟雾吸入介导的大鼠牙周炎骨吸收的抑制作用

用以调节宿主对牙周病反应的替代疗法已经在研究。了解治疗牙周炎的新方法对于患牙周炎高风险者尤为重要，如吸烟者。本研究的目的是调查白藜芦醇（RESV）对香烟吸入（CSI）对实验性牙周炎（EP）的影响。

Baidu
map
Baidu
map
Baidu
map