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Paediatric Anaesthesia:预防性使用右美托咪定预防小儿心脏手术后交界性异位性心动过速的疗效

2018-10-31 王贵龙 “罂粟花”微信号

预防性使用右美托咪定可明显降低先天性心脏手术儿童术后异位心动过速的发生率,并且无明显副作用。

背景与目的

术后交界性异位性心动过速是小儿心脏手术后最严重的心律失常之一,治疗困难,但预防效果良好。目的:评价预防性使用右美托咪定在预防小儿心脏手术后交界性异位性心动过速的疗效。

方  法

对90例因先天性心脏病行择期心脏手术患儿作前瞻性对照研究。将患儿随机分为2组,I组(右美托咪定组):60例患儿接受右美托咪定干预;II组(安慰剂组):30例患儿静脉应用等量生理盐水。

主要结局指标为术后交界性异位性心动过速的发生率,次要结局指标包括心动过缓、低血压、血管活性肌力评分、通气时间、儿科心脏监护病房留滞时间、住院时间和围手术期死亡率。

结  果

与安慰剂组(16.7%例)相比,右美托咪定组(3.3%例)异位性心动过速发生率明显降低(P<0.005)。右美托咪定组体外循环结束时心率(130.6±9)明显低于安慰剂组(144±7.1),P<0.001。右美托咪定组的平均通气时间、儿科心脏监护病房平均留滞时间和住院时间(天数)明显短于安慰剂组(p<0.001)。但两组在死亡率、心动过缓、低血压方面无显着差异 (P>0.005)。

结  论

预防性使用右美托咪定可明显降低先天性心脏手术儿童术后异位心动过速的发生率,并且无明显副作用。

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    2019-02-19 AspirantSuo
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
  7. 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encodeId=5daa15883423d, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Nov 02 09:28:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351100, encodeId=fe5e3511002a, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Oct 31 22:35:06 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-11-02 makuansheng
  8. 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encodeId=5daa15883423d, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Nov 02 09:28:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351100, encodeId=fe5e3511002a, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Oct 31 22:35:06 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-11-02 skhzy
  9. [GetPortalCommentsPageByObjectIdResponse(id=1978109, encodeId=7e5019e81095a, content=<a href='/topic/show?id=5b0a1366e45' target=_blank style='color:#2F92EE;'>#paediatric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13667, encryptionId=5b0a1366e45, topicName=paediatric)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Fri Mar 08 21:28:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633498, encodeId=733516334983e, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=5daa15883423d, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Nov 02 09:28:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351100, encodeId=fe5e3511002a, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Oct 31 22:35:06 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-10-31 天地飞扬

    了解一下,谢谢分享!

    0

  10. 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encodeId=5daa15883423d, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Nov 02 09:28:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351100, encodeId=fe5e3511002a, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Oct 31 22:35:06 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031959, encodeId=9bad1031959dd, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Wed Oct 31 21:28:00 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-10-31 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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