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Lancet Respir Med:新的临床规则帮助决定儿童咳嗽用不用抗生素

2016-09-02 MedSci MedSci原创

抗菌素耐药性是一个严重威胁公共健康的问题,大部分抗生素处方出自初级卫生保健。全科医生(GPs)报告开具防御性抗生素处方来减轻呼吸道感染儿童日后住院的风险。本研究开发了一个临床规则旨在通过对未来住院管理的风险分层来减少临床不确定性。 研究从247家全科医生门诊纳入8394名急性咳嗽(≤28天)和呼吸道感染的儿童,年龄在3个月到16岁之间。曝光变量包括人口统计学特征,父母报告的症状,和身体检查征

抗菌素耐药性是一个严重威胁公共健康的问题,大部分抗生素处方出自初级卫生保健。全科医生(GPs)报告开具防御性抗生素处方来减轻呼吸道感染儿童日后住院的风险。本研究开发了一个临床规则旨在通过对未来住院管理的风险分层来减少临床不确定性。

研究从247家全科医生门诊纳入8394名急性咳嗽(≤28天)和呼吸道感染的儿童,年龄在3个月到16岁之间。曝光变量包括人口统计学特征,父母报告的症状,和身体检查征象。结果是呼吸道感染在30天内入院治疗;

最终8394名(100%)儿童纳入分析,其中78名(0.9%,95% CI 0.7%-1.2%)儿童入院治疗:15名(19%)招募时入院(第1天),33名(42%)第2-7天,30名(39%)第8-30天。七个特征与住院独立相关(P<0.01):年龄<2岁,哮喘,病程≤3天,父母报告前24小时儿童中度或重度呕吐,父母报告前24小时儿童高烧或体温≥37.8°C,临床医生报告肋间或肋下凹陷,和临床医生报告听诊哮鸣音。临床规则系数的AUROC曲线为0.82(95% CI 0.77–0.87、引导验证0.81)。每个特征指定一点,以点为基础的临床规则,包括突发疾病、体温、年龄、凹陷、喘息、哮喘、呕吐(mnemonic STARWAVe;;AUROC, 0. 81,0.76-0.85)来区分三种住院的风险分层:非常低(0.3%,0.2 -0.4%),≤1点特征;正常(1.5%,1.0–1.9%),2或3点特征;高(11.8%, 7.3 -16 2%),≥4点特征。

临床特征可以区分未来非常低、正常和高风险入院治疗呼吸道感染的儿童,并可以用来减少初级保健中风险极低的儿童抗生素处方的使用。

原始出处:

Alastair D Hay, et a., Development and internal validation of a clinical rule to improve antibiotic use in children presenting to primary care with acute respiratory tract infection and cough: a prognostic cohort study.  Lancet Respir Med2016; doi:10.1016/S2213-2600(16)30223-5.

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    2016-09-24 howi
  3. 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    2016-09-06 1e0d99ddm02(暂无匿称)

    新的临床规则应该是,白毛黑猫逮着老鼠就是好猫!

    0

  4. 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createdName=howi, createdTime=Sat Sep 24 17:40:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112413, encodeId=2476112413ff, content=新的临床规则应该是,白毛黑猫逮着老鼠就是好猫!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 16:12:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112386, encodeId=7a921123867b, content=写的很好,赞一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112388, encodeId=5e59112388e2, content=可以接入临床!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112387, encodeId=5b1a11238e5b, content=写的不错,分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110962, encodeId=4a831109627f, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 20:58:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607079, encodeId=b343160e07988, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 04 10:40:00 CST 2016, time=2016-09-04, status=1, ipAttribution=)]
    2016-09-06 1e0d99ddm02(暂无匿称)

    写的很好,赞一下!

    0

  5. 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createdName=howi, createdTime=Sat Sep 24 17:40:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112413, encodeId=2476112413ff, content=新的临床规则应该是,白毛黑猫逮着老鼠就是好猫!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 16:12:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112386, encodeId=7a921123867b, content=写的很好,赞一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112388, encodeId=5e59112388e2, content=可以接入临床!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112387, encodeId=5b1a11238e5b, content=写的不错,分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110962, encodeId=4a831109627f, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 20:58:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607079, encodeId=b343160e07988, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 04 10:40:00 CST 2016, time=2016-09-04, status=1, ipAttribution=)]
    2016-09-06 1e0d99ddm02(暂无匿称)

    可以接入临床!

    0

  6. 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createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112388, encodeId=5e59112388e2, content=可以接入临床!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112387, encodeId=5b1a11238e5b, content=写的不错,分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111443, encodeId=a14f1114431d, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 11:13:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111395, encodeId=d8d4111395f2, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110962, encodeId=4a831109627f, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 20:58:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607079, encodeId=b343160e07988, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 04 10:40:00 CST 2016, time=2016-09-04, status=1, ipAttribution=)]
    2016-09-06 1e0d99ddm02(暂无匿称)

    写的不错,分享!

    0

  7. 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createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112388, encodeId=5e59112388e2, content=可以接入临床!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112387, encodeId=5b1a11238e5b, content=写的不错,分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111443, encodeId=a14f1114431d, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 11:13:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111395, encodeId=d8d4111395f2, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110962, encodeId=4a831109627f, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 20:58:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607079, encodeId=b343160e07988, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 04 10:40:00 CST 2016, time=2016-09-04, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110962, encodeId=4a831109627f, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 20:58:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607079, encodeId=b343160e07988, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 04 10:40:00 CST 2016, time=2016-09-04, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  9. 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createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Tue Sep 06 15:42:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111443, encodeId=a14f1114431d, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 11:13:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111395, encodeId=d8d4111395f2, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 10:46:00 CST 2016, time=2016-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110962, encodeId=4a831109627f, content=赞!好文章,拜读,值得深入学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 20:58:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607079, encodeId=b343160e07988, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Sep 04 10:40:00 CST 2016, time=2016-09-04, status=1, ipAttribution=)]
    2016-09-04 ylzr123

    赞!好文章,拜读,值得深入学习!

    0

  10. 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Nature:疫苗接种或可减少低收入国家抗生素耐药

一位年轻护士正准备给一个小孩接种肺炎链球菌和轮状病毒疫苗。 在非洲,随着肺炎链球菌疫苗接种的推行,抗生素抵抗的境况有所减轻。 今年夏天,厄立特里亚、科特迪瓦和尼日尔也将开始为婴儿接种由肺炎链球菌(Streptococcus pneumoniae)疫苗,从而预防由其所导致的肺炎、脑膜炎及其它致命性的疾病。在低收入国家,肺炎是年幼儿童的头号杀手;根据位于日内瓦的全

WHO:世界抗生素耐药性实况报道、认知误解及战略目标

重要事实 如今,抗生素耐药性是对全球卫生的最大威胁。它会影响每个人,无论其年龄和国籍。 抗生素耐药性是自然发生的,但在人类和动物间误用抗生素会加速发生耐药的过程。 越来越多的感染(比如肺炎、结核和淋病)变得更难治疗,原因在于用于治疗感染的抗生素不如原来有效。 抗生素耐药性会导致更长的住院时间,更高的医疗费用和更多死亡。 概况 抗生素是

Nat Microbiol:科学家阐明抵御超级细菌的新思路

来自澳大利亚的研究人员近日通过研究发现了一种阻断细菌致死性感染的新方法,该研究或为后期科学家们开发抵御超级耐药细菌的新型疗法提供帮助,相关研究刊登于国际杂志Nature Microbiology上。

WHO:世界抗生素耐药性实况报道及战略目标

重要事实 如今,抗生素耐药性是对全球卫生的最大威胁。它会影响每个人,无论其年龄和国籍。 抗生素耐药性是自然发生的,但在人类和动物间误用抗生素会加速发生耐药的过程。 越来越多的感染(比如肺炎、结核和淋病)变得更难治疗,原因在于用于治疗感染的抗生素不如原来有效。 抗生素耐药性会导致更长的住院时间,更高的医疗费用和更多死亡。 概况 抗生素是用于

PLoS Genet:GWAS查找细菌耐药的遗传学原因

最近,研究人员开发出一种强大的新工具,来识别抗生素耐药性致病菌中的遗传变化。这种技术所得到的结果,可在未来十年内应用于临床,决定肺炎和脑膜炎这类疾病的最有效治疗方法。相关研究结果发表在2014年8月7日的PLOS Genetics杂志。[pdf free] 研究小组着眼于肺炎链球菌(Streptococcus pneumoniae)的基因组,这种细菌每年导致全球160

呼吁:全球合作治理耐药危机

  全球消灭天花等事件证明一个应对公共健康威胁的国际机制是可以起到作用的。我们必须进行尝试,否则抗生素药物所获得的健康成果可能会因此消失。 发展中国家不受管制的药物销售造成抗生素耐药性的增加。图片来源:ISSOUF SANOGO   上个月,世界卫生组织(WHO)制作了一张抗生素耐药性的全球地图,警告称一个“后抗生素”的世界可能很快会成为现实。然而从某些

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