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JCEM:成年人空腹血糖受损风险与认知功能的相关性

2015-10-08 徐媛 MedSci原创

虽然糖代谢是认知能力下降的一个危险因素,但对于青少年来说,空腹血糖受损风险升高与青春期晚期认知功能降低是否相关,尚且未知。本项研究描述了认知功能与空腹血糖受损(IFG)之间的关系。来自以色列夏巴医学中心的研究人员进行了一项回顾性队列研究,研究人员收纳了17348名血糖正常的成年人(平均年龄31.0±5.6岁,男性占87%)并对这些成年人进行生活方式和营养状况进行评估。17岁时一般智力分数(GIS)

虽然糖代谢是认知能力下降的一个危险因素,但对于青少年来说,空腹血糖受损风险升高与青春期晚期认知功能降低是否相关,尚且未知。本项研究描述了认知功能与空腹血糖受损(IFG)之间的关系。

来自以色列夏巴医学中心的研究人员进行了一项回顾性队列研究,研究人员收纳了17348名血糖正常的成年人(平均年龄31.0±5.6岁,男性占87%)并对这些成年人进行生活方式和营养状况进行评估。17岁时一般智力分数(GIS)作为认知功能研究数据。每3-5年计划检测所收纳成年人空腹血糖水平。Cox比例风险模型也被使用。

在中位随访6.6年期间,有1478名IFG新发患者,其中1402名为男性。在调整年龄和性别后,GIS最低组参与者的IFG发生风险是GIS最高组的1.9倍。在调整多变量年龄、性别、体重指数、空腹血糖,糖尿病的家族史,社会经济地位、教育、体力活动、吸烟状况、饮酒、早餐消费,甘油三酸酯水平,白细胞计数后发现,GIS最低组参与者的IFG发生风险是GIS最高组的2倍(HR 1.8,95% ci 1.4 = 1.4,p < 0.001)。在随访结束后根据BMI调整了模型的同时,将GIS作为连续变量处理,这些结果仍然不变。

以上研究表明,成年人空腹血糖受损风险升高与青春期晚期认知功能降低独立相关。

原始出处

Cukierman-Yaffe T1, Kasher-Meron M2, Fruchter E4, Gerstein HC5, Afek A1,6, Derazne E1,4, Tzur D4, Karasik A1,2, Twig G1.Cognitive Performance at Late Adolescence and the Risk for Impaired Fasting Glucose Among Young Adults.J Clin Endocrinol Metab. 2015 Oct 2


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    2016-06-26 achengzhao
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    2015-12-16 smallant2015
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    2015-10-08 三三五五

    看不太懂,很感兴趣研究方法

    0

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