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J Bone Miner Res:研究发现维生素D是慢性肾病患者的良药!

2017-10-27 佚名 Medicalxpress

根据10月17日在“骨矿物研究杂志”上发表的一项研究,对于慢性肾脏疾病(CKD)患者,胆钙化醇补充可以纠正维生素D缺乏症并改善骨转换的标志物。

根据10月17日在“骨矿物研究杂志”上发表的一项研究,对于慢性肾脏疾病(CKD)患者,胆钙化醇补充可以纠正维生素D缺乏症并改善骨转换的标志物。

来自印度医学教育与研究所的Ashok Kumar Yadav博士及其同事检查了完成随机试验的受试者的骨转换,该研究检查了胆钙化补充对CKD期糖尿病患者(G3-4和维生素D≤20ng/ ml)血管功能的影响。参与者在基线和8周(58和59个患者分别完成研究)。被随机分为接受两个口服剂量的30万IU胆钙化醇或匹配的安慰剂。

研究人员发现,16周时胆钙化醇组血清25-羟基维生素D(25 [OH] D)和1,25-二羟基胆钙化醇(1,25 [OH] 2D)水平显着增加。胆钙化醇组的完整甲状旁腺激素(iPTH)显着降低。在胆钙化醇组中的血清总和骨特异性碱性磷酸酶(SAP,BAP)和血清C末端交联胶原I型肽(CTX-1)中观察到显着降低。相关分析中Δ25(OH)D与ΔiPTH,Δ1,25(OH)2D,ΔSAP,ΔBAP和ΔCTX-1有显着的相关性。

作者写道:“胆钙化甾醇补充修正维生素D缺乏症,有效降低CKD早期血清完整甲状旁腺激素和骨转换标志物。”

原始出处:
Yadav AK, Kumar V, Kumar V, et al.The Effect of Vitamin D Supplementation on Bone Metabolic Markers in Chronic Kidney Disease.J Bone Miner Res. 2017 Oct 17. doi: 10.1002/jbmr.3314. [Epub ahead of print]

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    2018-06-30 apoenzyme
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    2017-10-27 惠映实验室

    学习了.谢谢.

    0

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