Clin Chem：偶尔和长期吸食大麻者模拟驾驶对警惕性和事故风险的影响及其药代动力学-药效学关系

2019-07-21 不详 MedSci原创

目前，有关全血δ<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-family:"Times New Ro

目前，有关全血δ-9-四氢大麻酚（THC）与驱动风险之间的药代动力学 - 药效学关系知之甚少。

本研究包括年龄18至34岁的15例慢性大麻使用者(每天1-2支;CC)和15名偶尔吸食大麻者(每周1-2次;OC）。在控制随机吸入安慰剂或10mg或30mg THC之前和之后的24小时内进行12次血液采样的药代动力学研究。通过精神运动警戒测试和通过约克驾驶模拟器的驾驶性能对反应时间的影响对参与者评估7次。使用LC-MS / MS定量THC和代谢物。采用R软件进行药代动力学-药效学分析。

研究显示，在相同剂量下，CC组全血THC峰值是OC组的2倍，且发生在用药结束后5分钟。THC只有在24小时后才能在CC中检测到。反应时间的最大影响是剂量和分组，而对于驾车表现只有分组因素影响，在OC组中，下降更明显。这些作用在给药后5小时左右达到最大，OC组持续时间较CC组长。研究仅在血液THC的T_max和对平均倒数反应时间的持续时间影响之间观察到显著的药代动力学 - 药效学关系。

研究表明，大麻吸入导致血液THC快速增加，警惕性和驾驶性能延迟下降，OC较CC更明显，持续时间更长。

原始出处：

Sarah Hartley, Nicolas Simon,Effect of Smoked Cannabis on Vigilance and Accident Risk Using Simulated Driving in Occasional and Chronic Users and the Pharmacokinetic–Pharmacodynamic Relationship

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2020-01-15 hanhaisha2008

#吸食大麻#

71 0
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2019-11-19 fengyqf

#药代#

68 0
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2020-05-01 lsndxfj

#药效#

135 0
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2019-11-03 liuhuangbo

#药效学#

110 0
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2019-07-23 kcb069

#大麻#

76 0
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2019-07-23 zhaojie88

#药代动力学#

91 0
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2019-07-22 1209e435m98(暂无昵称)

学习了，谢谢分享

112 0

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