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Gastroenterology:PDE5抑制剂有助于降低男性CRC风险

2019-05-27 MedSci MedSci原创

男性良性结直肠肿瘤人群接受PDE5抑制剂有助于降低结肠癌风险

模型研究发现磷酸二酯酶5(PDE 5)抑制剂对直肠癌(CRC)有化学预防作用。近日研究人员探讨了PDE 5抑制剂对结直肠良性肿瘤男性患者CRC风险的影响。

2005年7月至2015年3月,瑞典良性结直肠肿瘤男性患者参与研究,分析患者药物治疗情况,获得关于PDE5抑制剂处方和CRC诊断的信息。

研究期间共有4823名患者接受PDE5抑制剂处方;对于接受PDE5抑制剂的男性患者,CRC的发生率为2.64/1000人-年,而未接受人群为4.46/1000人-年。PDE5抑制剂使用与CRC风险之间存在显著负相关(调整HR=0.65),CRC风险降低与PDE5抑制剂累积剂量增加相关(p=.003)。与早期CRC相比(调整HR=0.70),PDE5抑制剂与晚期CRC风险的降低相关(调整HR=0.61),但差异不显著。

研究认为,男性良性结直肠肿瘤人群接受PDE5抑制剂有助于降低结肠癌风险。

原始出处:


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    2020-01-22 yxch36
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    2019-10-04 许安
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    2019-12-10 jklm09
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    2019-05-28 lovetcm

    相当于中医的温阳药物

    0

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