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Am J Gastroenterol:粪便免疫化学试验方案与结肠癌筛查参与率

2019-04-22 MedSci MedSci原创

研究认为,患者对FOB-Gold粪便免疫化学试验结肠癌筛查方案的接受程度较高,但作为初步筛查方案实施时,不同策略对CRC筛选的参与率影响不显著

粪便免疫化学试验(FIT)结肠癌(CRC)筛查的实际效果可能受到FIT方案的影响,近日研究人员比较了两种不同的CRC筛选方案的患者参与率。

研究在荷兰开展,所有受邀者接受2种方案(OC-Sensor 和 FOB-Gold)筛查,通过问卷评估两种方案的易用性。

42179人参与研究,21078人(50%)完成了2项测试,20727人(98%)返回了问卷。研究发现,FOB-Gold更容易被患者接受,与OC方案(5%)相比,参与者更喜欢FOB-Gold(36%)方案,但大多数人没有偏好(59%,p<0.001)。在随机试验中,在1923名受邀者参与者中,936人(48.7%)选择了FOB-Gold, 940人(48.9%)选择了OC-Sensor,差异仅为-0.2%。

研究认为,患者对FOB-Gold粪便免疫化学试验结肠癌筛查方案的接受程度较高,但作为初步筛查方案实施时,不同策略对CRC筛选的参与率影响不显著。

原始出处:


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beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2020-04-05 许安
  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-24 smartxiuxiu

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 22 09:03:44 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365064, encodeId=88a836506438, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Mon Apr 22 07:13:23 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365062, encodeId=4f53365062ed, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-24 183****7028

    学习

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 22 09:03:44 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365064, encodeId=88a836506438, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Mon Apr 22 07:13:23 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365062, encodeId=4f53365062ed, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-23 Homburg
  8. [GetPortalCommentsPageByObjectIdResponse(id=1711920, encodeId=16eb1e11920a8, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Mon Jul 15 11:41:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772881, encodeId=8b7c1e72881ed, content=<a href='/topic/show?id=d7e1e6312cd' target=_blank style='color:#2F92EE;'>#粪便免疫化学试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76312, encryptionId=d7e1e6312cd, topicName=粪便免疫化学试验)], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 22 09:03:44 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365064, encodeId=88a836506438, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Mon Apr 22 07:13:23 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365062, encodeId=4f53365062ed, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 龙胆草

    学习谢谢分享

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Apr 22 09:03:44 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365064, encodeId=88a836506438, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Mon Apr 22 07:13:23 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365062, encodeId=4f53365062ed, content=学习了很有用不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 183****7028

    学习

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Apr 22 06:53:40 CST 2019, time=2019-04-22, status=1, ipAttribution=)]
    2019-04-22 飛歌

    学习了很有用不错

    0

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2019年3月,美国国家综合癌症网络(NCCN)发布了结肠癌指南2019年第1版,指南主要内容包括: 指南更新摘要 临床表现和主要治疗 病理分期,辅助治疗 监测 疾病复发和检查 肿瘤转移 影像学检查原则 病理检查 手术治疗原则 晚期和转移性疾病的系统治疗 放射治疗原则 Ⅱ期疾病风险评估 辅助治疗原则 生存者管理 分期

Gastroenterology:提高筛查率而非提前筛查是更具成本效益的结肠癌筛查方案

研究认为,在45岁开始进行CRC筛查具有一定的成本效益。然而通过提高未接受筛查的老年人和高风险人群的参与率,可以获得更大的利益

JAMA:化疗基础上添加高剂量VD3与晚期结肠癌患者临床收益

研究认为,对于转移性结肠癌患者,在化疗基础上添加高剂量VD3可略微延长患者无进展生存期,但对肿瘤客观治疗响应无显著影响,仍需采用进一步的研究确定VD3对晚期结肠癌的治疗收益

Am J Gastroenterol:结肠镜监测在控制溃疡性结肠炎进展中的作用

研究认为,接受结肠镜监测检查是有效的控制溃疡性结肠炎进展的方法,特别是直肠和乙状结肠应该进行更彻底的检查

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