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Mol Med Rep:circARRDC3促进白细胞介素-13诱导的鼻腔上皮细胞炎症细胞因子和粘液的产生

2021-01-15 AlexYang MedSci原创

过敏性鼻炎(AR)是一种常见的鼻黏膜炎症。它是哮喘发病的主要风险因素,且AR控制不佳可导致哮喘症状加重,影响患者的生活质量和生产效率。

过敏性鼻炎(AR)是一种常见的鼻黏膜炎症。它是哮喘发病的主要风险因素,且AR控制不佳可导致哮喘症状加重,影响患者的生活质量和生产效率。

据报道,循环RNA(circRNA)参与了AR的发病机制。最近,有研究人员调查了circRNA arrestin domain-containing 3(circARRDC3)在AR进展中的功能作用。结果表明,circARRDC3敲除可抑制IL-13诱导的鼻上皮细胞中粒细胞-巨噬细胞集落刺激因子(GM-CSF)和嗜酸细胞活化趋化因子(eotaxin)及粘蛋白5AC(MUC5AC)的水平。此外,circARRDC3沉默促进了IL-13诱导的NECs的活力,抑制了细胞凋亡。 circARRDC3能够靶向microRNA(miR)-375,并负调控其表达。miR-375的抑制能够逆转circARRDC3敲除对GM-CSF、eotaxin和MUC5AC表达水平、细胞活力和细胞凋亡的影响。此外,miR-375通过直接相互作用抑制了krueppel-like factor 4(KLF4)的表达,miR-375过表达抑制了GM-CSF、eotaxin和MUC5AC的表达水平以及细胞凋亡;而KLF4过表达后,这种抑制作用被消除。另外,AR患者鼻粘膜中circARRDC3、miR-375和KLF4均失调。miR-375表达与circARRDC3和KLF4表达呈负相关,circARRDC3表达与KLF4表达呈正相关。

circARRDC3调控IL-13诱导的炎症细胞因子,粘液产生和NECs的细胞生存和凋亡

最后,研究人员指出,circARRDC3通过调控miR-375/KLF4轴促进AR的发展。这些发现为AR的发病机制提供了新的见解

原始出处:

Tao Wang, Peihua Wang, Dong Chen et al. circARRDC3 contributes to interleukin 13 induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR 375/KLF4 axis. Mol Med Rep. 2021

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    2022-02-15 屋顶瞄爱赏月

    学习了

    0

  2. 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    2022-01-19 光明骑士

    儿童鼻炎

    0

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  4. 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  5. 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1193750, encodeId=3b831193e5077, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Tue Feb 15 21:16:24 CST 2022, time=2022-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1186015, encodeId=565f118601501, content=儿童鼻炎, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d585243593, createdName=光明骑士, createdTime=Wed Jan 19 14:18:28 CST 2022, time=2022-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046598, encodeId=1f812046598df, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809639, encodeId=1a32180963969, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Fri Oct 08 21:21:05 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917081, encodeId=a47191e08117, content=<a href='/topic/show?id=c0ae9405422' target=_blank style='color:#2F92EE;'>#过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=94054, encryptionId=c0ae9405422, topicName=过敏性鼻炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Sat Jan 16 07:54:31 CST 2021, time=2021-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283673, encodeId=74b112836e322, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Sun Jan 17 05:21:05 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465874, encodeId=e22114658e4c0, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Sun Jan 17 05:21:05 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533921, encodeId=a1c7153392175, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Sun Jan 17 05:21:05 CST 2021, time=2021-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610860, encodeId=57631610860bf, content=<a 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    展开1条回复
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809639, encodeId=1a32180963969, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Fri Oct 08 21:21:05 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917081, encodeId=a47191e08117, content=<a href='/topic/show?id=c0ae9405422' target=_blank style='color:#2F92EE;'>#过敏性鼻炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=94054, 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  8. 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    2021-01-17 mnda
  9. 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map