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Ann Neurol:酒精可改善肌阵挛性肌张力障碍患者的小脑学习缺陷

2017-11-01 zhangfan MedSci原创

研究发现对于阵挛性肌张力障碍患者,摄入酒精后其条件性的眨眼反应次数提高但眨眼反射恢复周期无显著变化,这说明阵挛性肌张力障碍患者小脑网络在联想学习与基底节-脑干相互作用中发挥的重要作用

近日研究人员考察了肌阵挛性肌张力障碍患者的神经生理学皮层下结构异常以及酒精的调节作用。

研究招募了17名肌阵挛性肌张力障碍患者,患者携带ε-肌聚糖(SGCE)基因突变,同时招募了21名年龄-性别匹配的健康对照者,对所有参与者进行小脑联想学习与基底节-脑干相互作用研究, 在吸入0.08%的乙醇前后进行经典眨眼条件反射和眨眼反射恢复周期考察并评估酒精吸入后的临床反应。

研究发现,在酒精吸入前,肌阵挛性肌张力障碍患者其条件性眨眼反应数目显著少于正常人群;在酒精吸入后,对照组条件性的眨眼反应数目显著下降,但肌阵挛性肌张力障碍患者的反应次数却上升(p=0.004)。组间酒精摄入前后眨眼反射恢复周期无显著差异。酒精摄入后肌阵挛性显著提高(p=0.016)。基线时的动作性肌阵挛的严重程度与患者眨眼条件反射的调节反应呈负相关。

研究发现对于阵挛性肌张力障碍患者,摄入酒精后其条件性的眨眼反应次数提高但眨眼反射恢复周期无显著变化,这说明阵挛性肌张力障碍患者小脑网络在联想学习与基底节-脑干相互作用中发挥的重要作用。

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    2018-05-09 yinhl1978
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    2018-06-21 zhmscau
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    2018-02-14 zxl729
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    2017-11-03 gujh

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