JCO：肥胖与蒽环霉素毒性有何关系？

2016-08-10 MedSci MedSci原创

研究人员通过进行研究后发现，乳腺癌患者的肥胖程度与蒽环霉素和曲妥珠单抗的毒性明显相关。Charles Guenancia博士指出，这项研究后的第一步是用数据确认超重和肥胖是蒽环霉素毒性的独立风险因素。他认为，如果前瞻性研究发现并不是由于其他因素导致肥胖患者较体形较瘦的患者出现并发症的发生率较高，则肥胖患者应配合做好心功能评估、随访调查和后续化疗。 7月26日临床肿瘤学杂志上发表的一篇文章中，Gue

研究人员通过进行研究后发现，乳腺癌患者的肥胖程度与蒽环霉素和曲妥珠单抗的毒性明显相关。

Charles Guenancia博士指出，这项研究后的第一步是用数据确认超重和肥胖是蒽环霉素毒性的独立风险因素。他认为，如果前瞻性研究发现并不是由于其他因素导致肥胖患者较体形较瘦的患者出现并发症的发生率较高，则肥胖患者应配合做好心功能评估、随访调查和后续化疗。

7月26日临床肿瘤学杂志上发表的一篇文章中，Guenancia博士和同事对15项相关研究进行了分析研究，共有8745名乳腺癌患者参与。他们发现，肥胖(BMI>30)或超重(BMI>25）的乳腺癌患者采用蒽环霉素和曲妥珠单抗化疗后出现毒性反应的风险更高。合并比值比为1.38，肥胖和超重的优势比分别为1.47和1.15。研究人员指出，体重和药物毒性之间的关联与实验设计、药物疗法、肥胖和超重定义、时间等因素无关。

亚组分析显示,BMI较高，则毒性风险逐渐增加。与正常体重的患者相比,超重和肥胖患者出现毒性反应的风险更大（OR分别为1.13和1.44)，肥胖患者较超重患者更甚(OR：1.27)。

研究人员承认,他们未调整一些因素，如糖尿病、高血压等心血管疾病风险因素，因此他们表示仍需进行更进一步的研究。

原始出处：

Obesity May Influence Anthracycline Cardiotoxicity,Medscape,9,Aug,2016

Charles Guenancia,et al,Obesity as a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: A Systematic Review and Meta-Analysis，J Clin Oncol,Jul,25,2016

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2016-12-18 lidong40

#JCO#

75 0
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2016-09-20 1e10c84am36(暂无匿称)

文章很好，非常有益

100 0
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2016-09-12 舒心和人

谨慎的态度是成功的基础，对于未知的领域心怀希望，认真求证才能不断进步

113 0
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2016-08-19 136****0753赵

值得学习

102 0
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2016-08-16 忠诚向上

好好学习一下

120 0
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2016-08-12 doctorJiangchao

继续关注

134 0
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2016-08-11 jaysppr

好文章，值得阅读，谢谢分享

73 0
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2016-08-11 jaysppr

好好学习

68 0

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