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JCEM:非酒精性脂肪肝和纤维化进展与慢性肾脏病发病风险相关

2021-07-03 MedSci原创 MedSci原创

NAFLD和纤维化进展与CKD发生风险增加相关。

非酒精性脂肪肝(NAFLD)的演变与慢性肾病(CKD)之间的关联尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估NALFD状态变化和NAFLD纤维化进展与CKD发生风险之间的关联。

研究人员进行了一项以社区为基础的前瞻性研究,参与者包括年龄40岁或以上且在2010年基线时无CKD的参与者,并在平均4.4年后进行随访。NAFLD是通过超声检查进行确诊。NAFLD 纤维化评分(NFS)用于评估纤维化阶段和进展情况。CKD是通过估计的肾小球滤过率(eGFR)或尿白蛋白肌酐比值(UACR)来定义的。所有测量均在基线和随访检查中进行。

CKD事件风险与NAFLD状态变化的关联

在4042名参与者中,与非NAFLD患者相比,NAFLD与CKD的风险增加相关(比值比,OR=1.44,95%置信区间[CI]为1.003-2.06;P=0.048),除基线水平外,还对混杂因素进行了调整,包括糖尿病、高血压和肥胖的演变情况。然而,NAFLD消除和NAFLD持续的患者之间CKD的发生风险没有显著差异。在持续性NAFLD的534名参与者中,与纤维化程度为低NFS的稳定患者相比,从低NFS进展到中度或高NFS的纤维化患者发生CKD的风险显著增加(OR=2.82,95%CI为1.22-6.56;P=0.016)。

由此可见,NAFLD和纤维化进展与CKD发生风险增加相关。

原始出处:

Guangmin Zuo.et al.New Nonalcoholic Fatty Liver Disease and Fibrosis Progression Associate With the Risk of Incident Chronic Kidney Disease.JCEM.2021.https://doi.org/10.1210/clinem/dgab425

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    2022-03-03 achengzhao
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style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Jul 05 03:01:11 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996220, encodeId=d0d39962204d, content=代谢性疾病本是一家, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 22:15:12 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995729, encodeId=b618995e2946, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5415146652, createdName=14689b06m31暂无昵称, createdTime=Sat Jul 03 15:24:10 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995704, encodeId=cc89995e04d6, content=脂肪肝,还是脂肪肝, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3ef5444455, createdName=ms4000002132796343, createdTime=Sat Jul 03 13:55:52 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995679, encodeId=96849956e9ea, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa591866, createdName=yuyan1859, createdTime=Sat Jul 03 12:04:32 CST 2021, time=2021-07-03, status=1, ipAttribution=)]
    2022-02-01 smallant2015
  5. 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  6. 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  7. 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    2021-07-04 63766754

    代谢性疾病本是一家

    0

  8. 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style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Jul 05 03:01:11 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996220, encodeId=d0d39962204d, content=代谢性疾病本是一家, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 22:15:12 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995729, encodeId=b618995e2946, content=<a href='/topic/show?id=1c1710265113' target=_blank 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level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa591866, createdName=yuyan1859, createdTime=Sat Jul 03 12:04:32 CST 2021, time=2021-07-03, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1673676, encodeId=9f8e16e3676ad, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Mon Sep 27 11:01:11 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063455, encodeId=7acb2063455c1, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, 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style='color:#2F92EE;'>#高血压#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5415146652, createdName=14689b06m31暂无昵称, createdTime=Sat Jul 03 15:24:10 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995704, encodeId=cc89995e04d6, content=脂肪肝,还是脂肪肝, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3ef5444455, createdName=ms4000002132796343, createdTime=Sat Jul 03 13:55:52 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995679, encodeId=96849956e9ea, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa591866, createdName=yuyan1859, createdTime=Sat Jul 03 12:04:32 CST 2021, time=2021-07-03, status=1, ipAttribution=)]
    2021-07-03 ms4000002132796343

    脂肪肝,还是脂肪肝

    0

  10. 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style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Mon Jul 05 03:01:11 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996220, encodeId=d0d39962204d, content=代谢性疾病本是一家, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdb2944259, createdName=63766754, createdTime=Sun Jul 04 22:15:12 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995729, encodeId=b618995e2946, content=<a href='/topic/show?id=1c1710265113' target=_blank 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level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8aa591866, createdName=yuyan1859, createdTime=Sat Jul 03 12:04:32 CST 2021, time=2021-07-03, status=1, ipAttribution=)]
    2021-07-03 yuyan1859

    学习!

    0

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