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JACC:细胞外体积分数可独立预测主动脉瓣狭窄患者死亡率

2020-02-08 不详 MedSci原创

心肌纤维化是主动脉瓣狭窄患者左室失代偿的主要机制,且可用心脏磁共振(CMR)的细胞外体积分数(ECV)进行定量分析。本研究的目的旨在评估ECV%与左室失代偿和主动脉瓣狭窄介入治疗预后指标的相关性。本研究纳入分析了440名接受了CMR检测的重度主动脉瓣狭窄患者(平均年龄70±10岁,男性占59%),ECV%不随扫描仪制造商、磁场强度或T1映射序列的不同而改变。分析结果发现,ECV%与左室失代偿的指标

心肌纤维化是主动脉瓣狭窄患者左室失代偿的主要机制,且可用心脏磁共振(CMR)的细胞外体积分数(ECV)进行定量分析。本研究的目的旨在评估ECV%与左室失代偿和主动脉瓣狭窄介入治疗预后指标的相关性。

本研究纳入分析了440名接受了CMR检测的重度主动脉瓣狭窄患者(平均年龄70±10岁,男性占59%),ECV%不随扫描仪制造商、磁场强度或T1映射序列的不同而改变。分析结果发现,ECV%与左室失代偿的指标呈相关性(p < 0.05),经过平均3.8年时间的随访,52名患者死亡,ECV%越高患者的死亡风险越高,ECV%不仅与心源性死亡率呈相关性,也与全因死亡率呈独立相关性,

研究结果显示,对于重度主动脉瓣狭窄患者,细胞外体积分数与心肌纤维化程度相关,且可独立预测患者的死亡率。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权


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    2020-02-15 hbwxf
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