Baidu
map

Oncotarget:番红花酸或可有效抑制胰腺癌癌细胞的生长

2015-11-05 MedSci MedSci原创

Oncotarget:Crocetinic酸或可有效抑制胰腺癌癌细胞的生长近些年来,来自勘萨斯大学医学中心的癌症生物学系的研究人员一直在研究番红花酸对胰腺癌的作用。番红花酸来自藏红花,一种流行的香料和食品着色剂,是很多印度传统药物的关键成分。据发表于Oncotarget的一项新的研究表明,Crocetinic酸——从番红花酸中纯化出来的复合物,可抑制胰腺癌细胞的生长。Animesh Dhar博士说

近些年来,来自勘萨斯大学医学中心的癌症生物学系的研究人员一直在研究番红花酸对胰腺癌的作用。番红花酸来自藏红花,一种流行的香料和食品着色剂,是很多印度传统药物的关键成分。

据发表于Oncotarget的一项新的研究表明,Crocetinic酸——从番红花酸中纯化出来的复合物,可抑制胰腺癌细胞的生长。

Animesh Dhar博士说道,应用Crocetinic酸21天后,小鼠皮下的胰腺癌组织生长明显减慢。“相比于未接受Crocetinic酸治疗的小鼠,接受Crocetinic酸治疗的小鼠其癌组织的生长速度下降了75%,未接受Crocetinic酸治疗的小鼠其癌组织体积增加了250%”

胰腺癌是最致命的癌症之一,是美国群众因癌症死亡的第四大病因,每年超43000人诊断出患有胰腺癌,且每年因胰腺癌死亡的人数也约43000人。目前仅有3%的胰腺癌患者在确诊后可存活5年以上。

KU医学中心的试验表明,Crocetinic酸可靶向并抑制胰腺癌干细胞——通常可抗传统化疗药物的一群致死性的细胞。

“除非破坏这些细胞,否则癌症还可复发,” Shrikant Anant博士说道,“如果我们可以确定Crocetinic酸可成功的抑制或破坏这些干细胞,那么这将是胰腺癌治疗上的一大进步。

原始出处:

Crocetinic acid in saffron may inhibit the pancreatic cancer cell growth. Science Daily,November 2, 2015.


Rangarajan P, Subramaniam D, Paul S, Kwatra D, Palaniyandi K, Islam S, Harihar S, Ramalingam S, Gutheil W, Putty S, Pradhan R, Padhye S, Welch DR, Anant S, Dhar A. Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells. Oncotarget. 2015 Sep 29;6(29):27661-73.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2061131, encodeId=ea5b2061131ca, content=<a href='/topic/show?id=ccfa6061407' target=_blank style='color:#2F92EE;'>#有效抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60614, encryptionId=ccfa6061407, topicName=有效抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Wed Jun 08 04:33:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795321, encodeId=9b881e9532138, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sat May 28 22:33:00 CST 2016, time=2016-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42677, encodeId=3d86426e722, content=胰腺癌是治疗效果最差的肿瘤之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Nov 06 19:57:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252055, encodeId=ca731252055e0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Nov 06 15:33:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42573, encodeId=4a9f425e3ea, content=可以跟踪, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Nov 05 08:12:00 CST 2015, time=2015-11-05, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2061131, encodeId=ea5b2061131ca, content=<a href='/topic/show?id=ccfa6061407' target=_blank style='color:#2F92EE;'>#有效抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60614, encryptionId=ccfa6061407, topicName=有效抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Wed Jun 08 04:33:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795321, encodeId=9b881e9532138, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sat May 28 22:33:00 CST 2016, time=2016-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42677, encodeId=3d86426e722, content=胰腺癌是治疗效果最差的肿瘤之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Nov 06 19:57:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252055, encodeId=ca731252055e0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Nov 06 15:33:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42573, encodeId=4a9f425e3ea, content=可以跟踪, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Nov 05 08:12:00 CST 2015, time=2015-11-05, status=1, ipAttribution=)]
    2016-05-28 闆锋旦
  3. [GetPortalCommentsPageByObjectIdResponse(id=2061131, encodeId=ea5b2061131ca, content=<a href='/topic/show?id=ccfa6061407' target=_blank style='color:#2F92EE;'>#有效抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60614, encryptionId=ccfa6061407, topicName=有效抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Wed Jun 08 04:33:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795321, encodeId=9b881e9532138, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sat May 28 22:33:00 CST 2016, time=2016-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42677, encodeId=3d86426e722, content=胰腺癌是治疗效果最差的肿瘤之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Nov 06 19:57:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252055, encodeId=ca731252055e0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Nov 06 15:33:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42573, encodeId=4a9f425e3ea, content=可以跟踪, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Nov 05 08:12:00 CST 2015, time=2015-11-05, status=1, ipAttribution=)]
    2015-11-06 jetleo

    胰腺癌是治疗效果最差的肿瘤之一

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2061131, encodeId=ea5b2061131ca, content=<a href='/topic/show?id=ccfa6061407' target=_blank style='color:#2F92EE;'>#有效抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60614, encryptionId=ccfa6061407, topicName=有效抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Wed Jun 08 04:33:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795321, encodeId=9b881e9532138, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sat May 28 22:33:00 CST 2016, time=2016-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42677, encodeId=3d86426e722, content=胰腺癌是治疗效果最差的肿瘤之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Nov 06 19:57:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252055, encodeId=ca731252055e0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Nov 06 15:33:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42573, encodeId=4a9f425e3ea, content=可以跟踪, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Nov 05 08:12:00 CST 2015, time=2015-11-05, status=1, ipAttribution=)]
    2015-11-06 yxch36
  5. [GetPortalCommentsPageByObjectIdResponse(id=2061131, encodeId=ea5b2061131ca, content=<a href='/topic/show?id=ccfa6061407' target=_blank style='color:#2F92EE;'>#有效抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60614, encryptionId=ccfa6061407, topicName=有效抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69cb413, createdName=chengjn, createdTime=Wed Jun 08 04:33:00 CST 2016, time=2016-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1795321, encodeId=9b881e9532138, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8409354, createdName=闆锋旦, createdTime=Sat May 28 22:33:00 CST 2016, time=2016-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42677, encodeId=3d86426e722, content=胰腺癌是治疗效果最差的肿瘤之一, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bfa83595, createdName=jetleo, createdTime=Fri Nov 06 19:57:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252055, encodeId=ca731252055e0, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Fri Nov 06 15:33:00 CST 2015, time=2015-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=42573, encodeId=4a9f425e3ea, content=可以跟踪, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8c171373773, createdName=gzhjjx, createdTime=Thu Nov 05 08:12:00 CST 2015, time=2015-11-05, status=1, ipAttribution=)]
    2015-11-05 gzhjjx

    可以跟踪

    0

相关资讯

新型尿检方法诊断胰腺癌准确率达90%!

随着医学的发展,人们已经意识到了疾病检查方法与治疗手段同样重要。这个道理在肿瘤的治疗和预防中显得尤为重要。据此,长期以来世界各国的科学家们都致力于开发新的肿瘤检测方法。 最近来自英国和西班牙的科学家开发出了一种新型尿检方法有望提高检测胰腺癌的效率,这一结果也已经被发表在Clinical Cancer Research。 胰腺癌是一种恶性肿瘤,当现有检查手段确诊胰腺癌时,这种疾病往往已经发展

Ann Surg:不可逆电穿孔技术或可有效延长胰腺癌患者的生存率

近日,一项发表于国际杂志the Annals of Surgery上的研究论文中,来自路易斯维尔大学(University of Louisville)的研究人员通过研究表示,在胰腺癌细胞中实施不可逆地电穿孔(IRE)或可改善某些患者的生存率。研究者Robert Martin II博士表示,对胰腺癌患者进行手术完全移除癌症组织是不可能的,当前研究中我们对200名成年III期胰腺癌患者进行研究,在患

Nat med:药物联用治疗胰腺癌显奇效

根据斯坦福大学医学院的一项最新研究,将两种药物联合使用可以有效治疗实验小鼠的胰腺癌,其中一种药物已经得到了美国FDA的批准。相关研究结果发表在国际学术期刊Nature medicine上。   这两种药物可以影响癌细胞DNA的结构和功能,而非癌细胞内的蛋白质活性,除了能够治疗胰腺癌,这种联合使用还可以减缓人类肺癌细胞在小鼠体内的生长,这项研究找到了这些类型药物治疗疾病的潜在作用,研

Science signaling:胰腺癌转移新套路——借力神经转移

近日,来自美国约翰霍普金斯Kimmel癌症中心的科学家在胰腺癌细胞中发现一种新的分子关系能够帮助解释胰腺癌转移的原因。美国每年有大约50,000人罹患胰腺癌,并且诊断后的5年生存率只有5%,而这一研究发现的促癌转移关键分子可能为胰腺癌治疗提供新的靶点。Annexin A2是一种参与多种癌症并导致病人生存率低下的蛋白分子。在这项发表在国际学术期刊science signaling的研究中,研究人员发

Surgery:为什么早期胰腺癌的老年患者手术率那么低?

对于早期胰腺癌患者,尽早的手术治疗可以显著患者的健康治疗和临床结局,但历史数据显示该类患者的手术比例很低。研究者进行了一项基于人群的回顾性研究,欲探究该类患者有哪些因素会影响到手术的选择。研究者纳入了2001年1月1日-2009年12月31日的年龄≥66岁的早期小范围局部的胰腺癌患者,通过德州癌症数据以及相关医疗数据收集与手术切除相关的潜在影响因素。通过多因素回归模型和Cox风险比例模型对变量和数

Pancreas:牙周病可增加胰腺癌的发病风险

Pancreas:牙周病可增加机体胰腺癌的发病风险目前,公众逐渐认识到牙周病是系统性疾病的的一个危险因素,目前已知的相关的系统性疾病包括糖尿病、心血管疾病及癌症等。本研究旨在探究牙周病(牙龈炎,牙周炎及其他牙周性疾病)与胰腺癌之间的关系。研究共纳入139805名牙周炎患者以及75085名非牙周炎对照者。使用Cox比例风险回归模型对比两组研究对象胰腺癌的发病率。结果发现,牙周病与胰腺癌的发生呈正相关

Baidu
map
Baidu
map
Baidu
map