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遗传学研究揭示了骨关节炎新的治疗靶点

2019-01-28 MedSci MedSci原创

Sanger研究所、GSK及其合作者组成的研究小组发现了52种与骨关节炎相关的新的遗传变化,将与致残疾病相关的遗传区域扩大了一倍。该研究将为骨关节炎的新靶点的开发铺平道路。

Sanger研究所、GSK及其合作者组成的研究小组发现了52种与骨关节炎相关的新的遗传变化,将与致残疾病相关的遗传区域扩大了一倍。该研究将为骨关节炎的新靶点的开发铺平道路。

该研究一共分析了超过77000名骨关节炎患者和超过370000名健康人的全基因组,揭示了与骨关节炎相关的新基因和生物学途径,这不仅有助于开发骨关节炎的新药,还可以对现有药物进行评估。

骨关节炎是最普遍的肌肉骨骼疾病,并且是全世界残疾的主要原因。在英国,目前有近千万人患有骨关节炎,间接地导致每年的经济损失达148亿英镑。目前用于缓解该疾病疼痛的方法只能通过药物进行管理

Versus Arthritis研究主任Stephen Simpson博士评价说:"这项研究是了解骨关节炎复杂性和寻找新疗法的重要里程碑,我们很高兴为这项研究有所支持。从长远来看,这项研究在结束关节炎患者的疼痛的过程中取得了显着进展。"

原始出处:

http://www.pharmatimes.com/news/genetic_study_reveals_possible_newosteoarthritis_treatment_1275802

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    2019-05-29 lisa438
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    2019-01-30 lmm397
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    2019-01-29 lietome15

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2026617, encodeId=9689202661e4e, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Wed May 29 02:55:00 CST 2019, time=2019-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843974, encodeId=c72218439e410, content=<a href='/topic/show?id=05e29508559' target=_blank style='color:#2F92EE;'>#遗传学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95085, encryptionId=05e29508559, topicName=遗传学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e7948, createdName=李研东, createdTime=Thu Sep 12 19:55:00 CST 2019, time=2019-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974277, encodeId=a17d19e4277bb, content=<a href='/topic/show?id=08829509851' target=_blank style='color:#2F92EE;'>#遗传学研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95098, encryptionId=08829509851, topicName=遗传学研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Sep 23 11:55:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895377, encodeId=a0eb18953e75b, content=<a href='/topic/show?id=18ae64e21d3' target=_blank style='color:#2F92EE;'>#治疗靶点#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64721, encryptionId=18ae64e21d3, topicName=治疗靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Sat Nov 30 01:55:00 CST 2019, time=2019-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265902, encodeId=049f12659023a, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Wed Jan 30 06:55:00 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359504, encodeId=ce5e35950469, content=好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Tue Jan 29 11:33:07 CST 2019, time=2019-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359448, encodeId=988f359448d9, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=d85d1636106, createdName=lietome2, createdTime=Mon Jan 28 17:22:10 CST 2019, time=2019-01-28, status=1, ipAttribution=)]
    2019-01-28 lietome2

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

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TOMS的纵向可靠性为中等至良好。很少有变化阻碍评估。

Baidu
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