Sci Rep：激活受体酪氨酸激酶AXL的细胞软化在人类肺癌细胞恶性进展中的作用

2017-12-25 xiangting MedSci原创

AXL活化诱导的细胞软化促进了非小细胞肺癌的恶性进展，并且代表了癌细胞的关键生物物理特性。

这项研究旨在探讨细胞软化在恶性进展中的作用。

使用Transwell分析和原子力显微镜将6种人类非小细胞肺癌细胞系分为两组：高运动性-低强度（HMLS）组和低运动性-高强度（LMHS）组。研究人员发现了AXL受体酪氨酸激酶（它属于TAM（Tyro3，AXL，Mer）家族）在活动性刺激和细胞软化中的重要作用。HMLS细胞比LMHS细胞表达的AXL水平更高，并含有磷酸化AXL。用外源AXL转染的H1703 LMHS细胞表现出运动性升高和强度降低，肌动蛋白纤维形成水平低。相反，AXL特异性抑制剂R428和AXL靶向siRNA降低了H1299 HMLS细胞的运动性和增加了强度。敲除AXL刺激肌动蛋白纤维形成，这抑制了小鼠异种移植模型中的肿瘤形成。阻断肌动蛋白应力纤维破坏的Ras / Rac抑制剂SCH51344对AXL失活有类似的作用。因此认为Ras / Rac通路在AXL下游起作用。

因此，AXL活化诱导的细胞软化促进了非小细胞肺癌的恶性进展，并且代表了癌细胞的关键生物物理特性。

原始出处：

Keisuke Iida, et al. Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL. Sci Rep. 19 December 2017.

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2018-03-20 luckyshitiancai_42705695

#酪氨酸激酶#

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2018-06-21 kalseyzl

#肺癌细胞#

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2018-02-23 135****7952平儿

学了......

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2018-11-03 feather78

#细胞软化#

91 0
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2017-12-27 yxch36

#癌细胞#

65 0
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2017-12-27 redcrab

#激酶#

116 0
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2017-12-25 131****1460

学习了受益匪浅

135 0
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2017-12-25 Jackie Li

学习

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