Nature：GDF15介导二甲双胍对体重和能量平衡的效应

2020-01-04 xing.T MedSci原创

总之，二甲双胍可提高循环中GDF15的水平，这对于其维持能量平衡和体重的有益作用是必需的，而GDF15作为其化学预防剂具有主要作用。

二甲双胍是世界上最广泛运用到处方中的抗糖尿病药物，也可有效预防高危人群中的2型糖尿病。这种作用60％以上归因于二甲双胍持续降低体重的功能。二甲双胍降低体重的分子机制尚不清楚。

近日，顶级期刊Nature上发表了一篇研究文章，在两项独立的随机对照临床试验中，二甲双胍可提高受试者循环中GDF15的水平，最近研究发现二甲双胍通过脑干限制性受体来减少食物摄入并降低体重。

在野生型小鼠中，口服二甲双胍可增加循环中的GDF15水平，而GDF15主要在远端肠道和肾脏中表达增加。在野生型小鼠中，二甲双胍阻止了高脂饮食诱导的体重增加，但在缺乏GDF15或其受体GFRAL的小鼠中却没有。在肥胖的高脂饮食小鼠中，二甲双胍减轻体重的作用被GFRAL拮抗剂抗体所逆转。二甲双胍需要GDF15才能对能量摄入和能量消耗产生效应。在没有GDF15作用的情况下，二甲双胍保持了降低循环葡萄糖水平的能力。

总之，二甲双胍可提高循环中GDF15的水平，这对于其维持能量平衡和体重的有益作用是必需的，而GDF15作为其化学预防剂具有主要作用。

原始出处：

Anthony P. Coll. et al. GDF15 mediates the effects of metformin on body weight and energy balance.Nature.2020.https://www.nature.com/articles/s41586-019-1911-y.

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2021-04-22 ms1000000765466241

受教了

104 0
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2020-11-03 lovetcm

#GDF-15#是长寿因子，#二甲双胍#抗#衰老#，可能与它也有关

183 0
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2020-07-07 liye789132251

#Nat#

74 0
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2020-01-06 zxl732

#能量平衡#

96 0
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2020-01-04 misszhang

二甲双胍，神药！

81 0

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