Baidu
map

Stroke:家族史对年轻卒中患者的影响

2015-06-03 崔倩 译 MedSci原创

背景:脑卒中家族史是脑卒中的一个危险因素。该研究目的是评估脑卒中家族史是否有一定的脑卒中的亚型以及在中青年脑卒中患者中会因性别而不同。    方法:该研究的数据来自于脑卒中患者的法布里研究,一个大型的前瞻性,以医院为基础,在年轻中风患者(年龄<55岁)筛选法布里病的研究,在这项研究中,中风患者的心血管危险因素和中风家族史得到细致的考察并进行分型。  &

背景:卒中家族史是脑卒中的一个危险因素。该研究目的是评估脑卒中家族史是否有一定的脑卒中的亚型以及在中青年脑卒中患者中会因性别而不同。
    
方法:该研究的数据来自于脑卒中患者的法布里研究,一个大型的前瞻性,以医院为基础,在年轻中风患者(年龄<55岁)筛选法布里病的研究,在这项研究中,中风患者的心血管危险因素和中风家族史得到细致的考察并进行分型。
    
结果:中风家族史在4232例短暂性脑缺血发作和缺血性卒中患者的1578例(37.3%)中体现。与父系血统相比,女性患者往往有更多的母系血统的中风史(P=0.027)。根据急性卒中治疗的Org 10172试验,并没有与卒中亚型以及脑白质病变的脑成像有关的现象。患者的解剖报告较少有中风家族史(30.4% vs 36.3%,P=0.018)。有父母脑卒中史的患者的兄弟姐妹卒中现象更常见(3.6% vs 2.6%,P=0.047)。
    
结论:虽然目前大约三分之一的脑卒中家族史患者,没有具体涉及到年轻脑卒中患者的中风的致病亚型。但母系血统中年轻女性中风更常见。

原始出处:

Vincent Thijs, MD, PhD, Ulrike Grittner, PhD, Martin Dichgans, MD, Christian Enzinger, MD, Franz Fazekas, MD, Anne-Katrin Giese, MD, Christof Kessler, MD, Edwin Kolodny, MD, Peter Kropp, PhD, Peter Martus, PhD, Bo Norrving, MD, Erich Bernd Ringelstein, MD, Peter M. Rothwell, FMedSci, Reinhold Schmidt, MD, Christian Tanislav, MD, Turgut Tatlisumak, MD, PhD, Bettina von Sarnowski, MD, Arndt Rolfs, MD, on behalf of the Stroke in Fabry Investigators*,Family History in Young Patients With Stroke.Stroke,2015.6.2

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1720044, encodeId=a1d11e2004438, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Oct 31 14:04:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479778, encodeId=752e14e9778ca, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 05 04:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25890, encodeId=80402589034, content=看来遗传和许多病相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKAfvF1yoI2FRuo7iaz5ia9jibNXCicXVVBw6AUvWhJ5DK4zmCVtD9Z39PLvib94KB67jr2pSugBkz71nA/132, createdBy=9a751499840, createdName=kuibaoli, createdTime=Thu Jun 04 06:52:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25870, encodeId=f9dc258e0d4, content=这是和性别有关啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Wed Jun 03 21:38:00 CST 2015, time=2015-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25842, encodeId=277e2584228, content=是不是和饮食习惯有关系?, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Wed Jun 03 15:50:00 CST 2015, time=2015-06-03, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1720044, encodeId=a1d11e2004438, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Oct 31 14:04:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479778, encodeId=752e14e9778ca, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 05 04:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25890, encodeId=80402589034, content=看来遗传和许多病相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKAfvF1yoI2FRuo7iaz5ia9jibNXCicXVVBw6AUvWhJ5DK4zmCVtD9Z39PLvib94KB67jr2pSugBkz71nA/132, createdBy=9a751499840, createdName=kuibaoli, createdTime=Thu Jun 04 06:52:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25870, encodeId=f9dc258e0d4, content=这是和性别有关啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Wed Jun 03 21:38:00 CST 2015, time=2015-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25842, encodeId=277e2584228, content=是不是和饮食习惯有关系?, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Wed Jun 03 15:50:00 CST 2015, time=2015-06-03, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1720044, encodeId=a1d11e2004438, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Oct 31 14:04:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479778, encodeId=752e14e9778ca, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 05 04:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25890, encodeId=80402589034, content=看来遗传和许多病相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKAfvF1yoI2FRuo7iaz5ia9jibNXCicXVVBw6AUvWhJ5DK4zmCVtD9Z39PLvib94KB67jr2pSugBkz71nA/132, createdBy=9a751499840, createdName=kuibaoli, createdTime=Thu Jun 04 06:52:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25870, encodeId=f9dc258e0d4, content=这是和性别有关啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Wed Jun 03 21:38:00 CST 2015, time=2015-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25842, encodeId=277e2584228, content=是不是和饮食习惯有关系?, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Wed Jun 03 15:50:00 CST 2015, time=2015-06-03, status=1, ipAttribution=)]
    2015-06-04 kuibaoli

    看来遗传和许多病相关

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1720044, encodeId=a1d11e2004438, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Oct 31 14:04:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479778, encodeId=752e14e9778ca, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 05 04:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25890, encodeId=80402589034, content=看来遗传和许多病相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKAfvF1yoI2FRuo7iaz5ia9jibNXCicXVVBw6AUvWhJ5DK4zmCVtD9Z39PLvib94KB67jr2pSugBkz71nA/132, createdBy=9a751499840, createdName=kuibaoli, createdTime=Thu Jun 04 06:52:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25870, encodeId=f9dc258e0d4, content=这是和性别有关啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Wed Jun 03 21:38:00 CST 2015, time=2015-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25842, encodeId=277e2584228, content=是不是和饮食习惯有关系?, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Wed Jun 03 15:50:00 CST 2015, time=2015-06-03, status=1, ipAttribution=)]
    2015-06-03 1dd7eb8am26(暂无匿称)

    这是和性别有关啊

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1720044, encodeId=a1d11e2004438, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Sat Oct 31 14:04:00 CST 2015, time=2015-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479778, encodeId=752e14e9778ca, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Fri Jun 05 04:04:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25890, encodeId=80402589034, content=看来遗传和许多病相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKAfvF1yoI2FRuo7iaz5ia9jibNXCicXVVBw6AUvWhJ5DK4zmCVtD9Z39PLvib94KB67jr2pSugBkz71nA/132, createdBy=9a751499840, createdName=kuibaoli, createdTime=Thu Jun 04 06:52:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25870, encodeId=f9dc258e0d4, content=这是和性别有关啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Wed Jun 03 21:38:00 CST 2015, time=2015-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25842, encodeId=277e2584228, content=是不是和饮食习惯有关系?, beContent=null, objectType=article, channel=null, level=null, likeNumber=160, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Wed Jun 03 15:50:00 CST 2015, time=2015-06-03, status=1, ipAttribution=)]
    2015-06-03 s312486

    是不是和饮食习惯有关系?

    0

相关资讯

Stroke:卒中时血清溶解性丝氨酸蛋白酶下降

溶解性丝氨酸蛋白酶在冠心病中降低的。鉴于心功能不全和卒中之间的关系,循环中的丝氨酸蛋白酶有可能成为卒中风险的候选标记。然而,循环中的丝氨酸蛋白酶和卒中之间的关系在人类中还没有得到研究。因此,我们的研究旨在明确卒中患者与以社区为基础的健康对照之间的关联。研究方法:研究共纳入481位缺血性卒中的患者,116位出血性卒中的患者以及2498位健康人作为对照。我们检测了血清溶解性丝氨酸蛋白酶以及一些与卒中相

Stroke:左心房增大是卒中复发的独立危险因素

已有充分的研究证据表明左心房增大(left atrial enlargement ,LAE)会增加脑卒中发生风险,但会不会增加卒中再次复发风险目前还不甚明确。为此为阐明左心房扩大和脑栓塞(隐源性卒中、心源性卒中)以及所有缺血性中风复发的关系,来自于美国迈阿密大学米勒医学院的研究者开展了一项研究,企图找到证据。研究者随访了来源于北曼哈顿中风研究(Northern Manhattan Stroke S

Stroke:卒中对认知能力下降的影响有种族差异吗?

    背景  由于急性脑卒中存在种族差异,并且卒中会影响认知健康或其他因素,黑人患老年痴呆症的风险是否较高我们并不知道。该研究探讨了认知衰退的种族差异是否可以通过黑人和白人之间卒中发生的频率和影响来解释。    方法  在和医疗数据有联系的全国代表性的健康与退休研究中(1998-2010年),4908名≥65岁的黑人和白人参与了此项研究

Stroke:降低血压在缺血性卒中早期作用的Meta分析

血压升高常见于缺血性卒中的急性期,但是如何应对这一情况的策略目前还没有被很好地建立。因此我们对在缺血性卒中早期旨在对比动态血压下降组和对照组的随机对照试验进行了Mete分析。研究方法:我们通过Pubmed、EMBASE以及Clinicaltrials收集了自1966年1月至2015年3月的相关研究数据。我们纳入分析的主要为缺血性卒中发病后3天内针对动态血压下降组和对照组进行比较的随机对照试验。初级

Stroke:可溶性CD40L是预测未来卒中的有效标志物

可溶性CD40配体(sCD40L)的升高已被证实与心血管事件相关,然而目前关于sCD40L在预测卒中复发方面的作用还尚不明确。研究方法:我们对3044位患有急性轻微卒中和短暂性脑缺血发作的连续患者的基线sCD40L水平进行了检测。这些患者之前已经加入针对急性无症状脑血管事件(CHANCE)高风险患者应用氯吡格雷的研究。我们利用cox比例风险模型评估sCD40L与卒中复发之间的关联。研究结果:经过对

Baidu
map
Baidu
map
Baidu
map