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Lancet HIV:Grazoprevir加Elbasvir可有效治疗HIV和HCV共感染的患者

2015-07-10 崔倩 译 MedSci原创

丙型肝炎病毒(HCV)感染是HIV-1患者发病和死亡的一个主要原因。C-EDGE CO-INFECTION 研究评估了grazoprevir(MK-5172)加elbasvir(MK-8742)对于同时感染HCV和HIV患者的有效性,安全性和耐受性。    在这个非对照、非随机的3期开放性的单臂研究中,有慢性HCV基因型1,4,6和HIV共感染并且未经过治疗的、有或无

丙型肝炎病毒(HCV)感染是HIV-1患者发病和死亡的一个主要原因。C-EDGE CO-INFECTION 研究评估了grazoprevir(MK-5172)加elbasvir(MK-8742)对于同时感染HCV和HIV患者的有效性,安全性和耐受性。
    
在这个非对照、非随机的3期开放性的单臂研究中,有慢性HCV基因型1,4,6和HIV共感染并且未经过治疗的、有或无肝硬化的患者、来自欧洲、美国、澳大利亚等九个国家的37个中心的患者。这些患者没有接受过任何抗逆转录病毒治疗(ART)或没有接受过至少8周的ART稳定治疗。所有患者接受每日一次的grazoprevir100mg加elbasvir50mg的固定剂量组合的片剂,连续12周。初级终点是12周治疗结束后(SVR12)持续病毒学应答(HCV RNA<15 IU/ mL)。有效分析的主要人群是那些接受研究治疗至少一个剂量的所有患者。
    
在2014年6月11日和2014年8月29日之间,218名患者参加此项研究,他们接受grazoprevir加elbasvir治疗12周,12周时所有人都完成了随访。由218例中的210(96%)例达到SVR12(95%Cl 92.9-98.4)。由于一个非病毒学原因,其中一个病人没有达到SVR12;还有7例患者无肝硬化复发(2例在随后证实为再感染)。所有35例肝硬化患者达到SVR12。最常见的不良事件是疲劳(29;13%),头痛(27;12%)和恶心(20;9%)。没有患者因为不良事件而停止治疗。两名患者在接受ART治疗时出现短暂的HIV病毒血症。
    
这个HCV治疗方案似乎是有效的,感染HIV的同时有或没有肝硬化的患者表现出良好的耐受性。这些数据与以前的临床试验中单一感染的人群所得到的数据是一致的。这种疗法在未来的3期试验研究中将继续进行。

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    2015-07-31 howi
  5. [GetPortalCommentsPageByObjectIdResponse(id=1714720, encodeId=300b1e1472029, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Thu Feb 18 03:26:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066314, encodeId=a92b2066314b7, content=<a href='/topic/show?id=77be30014f4' target=_blank style='color:#2F92EE;'>#共感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30014, encryptionId=77be30014f4, topicName=共感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Tue Sep 01 05:26:00 CST 2015, time=2015-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650075, encodeId=65a016500e5c9, content=<a href='/topic/show?id=1ede8252ab' target=_blank style='color:#2F92EE;'>#Grazoprevir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8252, encryptionId=1ede8252ab, topicName=Grazoprevir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a76f23955752, createdName=zgwhgch, createdTime=Thu Feb 04 13:26:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828173, encodeId=ad2818281e397, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Jul 31 00:26:00 CST 2015, time=2015-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32446, encodeId=860c32446de, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:38:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257607, encodeId=7986125e6075e, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603236, encodeId=b58a1603236eb, content=<a href='/topic/show?id=1e8866549f' target=_blank style='color:#2F92EE;'>#Elbasvir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6654, encryptionId=1e8866549f, topicName=Elbasvir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=011119003722, createdName=pcw112, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619412, encodeId=0e67161941248, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=)]
    2015-07-12 huaxipanxing

    看看

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1714720, encodeId=300b1e1472029, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Thu Feb 18 03:26:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066314, encodeId=a92b2066314b7, content=<a href='/topic/show?id=77be30014f4' target=_blank style='color:#2F92EE;'>#共感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30014, encryptionId=77be30014f4, topicName=共感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Tue Sep 01 05:26:00 CST 2015, time=2015-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650075, encodeId=65a016500e5c9, content=<a href='/topic/show?id=1ede8252ab' target=_blank style='color:#2F92EE;'>#Grazoprevir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8252, encryptionId=1ede8252ab, topicName=Grazoprevir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a76f23955752, createdName=zgwhgch, createdTime=Thu Feb 04 13:26:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828173, encodeId=ad2818281e397, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Jul 31 00:26:00 CST 2015, time=2015-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32446, encodeId=860c32446de, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:38:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257607, encodeId=7986125e6075e, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603236, encodeId=b58a1603236eb, content=<a href='/topic/show?id=1e8866549f' target=_blank style='color:#2F92EE;'>#Elbasvir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6654, encryptionId=1e8866549f, topicName=Elbasvir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=011119003722, createdName=pcw112, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619412, encodeId=0e67161941248, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=)]
    2015-07-12 ymljack
  7. [GetPortalCommentsPageByObjectIdResponse(id=1714720, encodeId=300b1e1472029, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Thu Feb 18 03:26:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066314, encodeId=a92b2066314b7, content=<a href='/topic/show?id=77be30014f4' target=_blank style='color:#2F92EE;'>#共感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30014, encryptionId=77be30014f4, topicName=共感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Tue Sep 01 05:26:00 CST 2015, time=2015-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650075, encodeId=65a016500e5c9, content=<a href='/topic/show?id=1ede8252ab' target=_blank style='color:#2F92EE;'>#Grazoprevir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8252, encryptionId=1ede8252ab, topicName=Grazoprevir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a76f23955752, createdName=zgwhgch, createdTime=Thu Feb 04 13:26:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828173, encodeId=ad2818281e397, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Jul 31 00:26:00 CST 2015, time=2015-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32446, encodeId=860c32446de, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:38:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257607, encodeId=7986125e6075e, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603236, encodeId=b58a1603236eb, content=<a href='/topic/show?id=1e8866549f' target=_blank style='color:#2F92EE;'>#Elbasvir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6654, encryptionId=1e8866549f, topicName=Elbasvir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=011119003722, createdName=pcw112, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619412, encodeId=0e67161941248, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=)]
    2015-07-12 pcw112
  8. [GetPortalCommentsPageByObjectIdResponse(id=1714720, encodeId=300b1e1472029, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Thu Feb 18 03:26:00 CST 2016, time=2016-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066314, encodeId=a92b2066314b7, content=<a href='/topic/show?id=77be30014f4' target=_blank style='color:#2F92EE;'>#共感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30014, encryptionId=77be30014f4, topicName=共感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Tue Sep 01 05:26:00 CST 2015, time=2015-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650075, encodeId=65a016500e5c9, content=<a href='/topic/show?id=1ede8252ab' target=_blank style='color:#2F92EE;'>#Grazoprevir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8252, encryptionId=1ede8252ab, topicName=Grazoprevir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a76f23955752, createdName=zgwhgch, createdTime=Thu Feb 04 13:26:00 CST 2016, time=2016-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828173, encodeId=ad2818281e397, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Fri Jul 31 00:26:00 CST 2015, time=2015-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32446, encodeId=860c32446de, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=164, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun Jul 12 16:38:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257607, encodeId=7986125e6075e, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603236, encodeId=b58a1603236eb, content=<a href='/topic/show?id=1e8866549f' target=_blank style='color:#2F92EE;'>#Elbasvir#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6654, encryptionId=1e8866549f, topicName=Elbasvir)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=011119003722, createdName=pcw112, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619412, encodeId=0e67161941248, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Jul 12 05:26:00 CST 2015, time=2015-07-12, status=1, ipAttribution=)]
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