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J Clin Periodontol:牙周治疗对糖尿病患者内皮祖细胞基因表达的影响

2017-12-13 MedSci MedSci原创

牙周炎与2型糖尿病(T2DM)和内皮功能障碍密切相关。本研究调查了牙周治疗对糖尿病患者内皮祖细胞(EPCs)免疫炎症基因表达的影响。

牙周炎与2型糖尿病(T2DM)和内皮功能障碍密切相关。本研究调查了牙周治疗对糖尿病患者内皮祖细胞(EPCs)免疫炎症基因表达的影响。

方法:将18例患有T2DM的中重度慢性牙周炎患者随机分为治疗组(口腔卫生指导(OHI),刮治和根面平整(n = 11)和仅使用OHI的对照组(n = 7)。在治疗前和治疗后6个月采集外周血样本进行EPC的生化分析和培养。首先评估来自治疗组的四个随机选择的患者中基于PCR阵列的84个Toll样受体信号相关基因的EPCs分析。然后通过qPCR在两组中进一步验证差异表达的基因。

结果:治疗组所有受试者的牙周状况均显着改善。在所测试的84个基因中,IL-6和IL-8转录物在治疗后显着下调超过两倍,并且通过qPCR在所有受试者中进一步验证(p <0.05)。

结论:这个研究初步表明,牙周治疗可能有助于显着降低EPCs中IL-6和IL-8基因免疫炎症基因的表达。

原始出处:

Yi Wang, et al. Periodontal treatment modulates gene expression of endothelial progenitor cells in diabetic patients. Journal of Clinical Periodontology. 2017 December. doi:10.1111/jcpe.12806

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    2017-12-14 lyh994

    为什么这些疾病是有关联的

    0

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    2017-12-14 飛歌

    学习了很有用

    0

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    2017-12-13 有备才能无患

    牙周炎与2型糖尿病(T2DM)和内皮功能障碍密切相关.本研究调查了牙周治疗对糖尿病患者内皮祖细胞(EPCs)免疫炎症基因表达的影响.

    0

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