CLIN CHEM：利用人体肝细胞代谢和高分辨率质谱区分析合成大麻素ADB-PINACA和5F-ADB-PINACA的摄入

2017-03-24 MedSci MedSci原创

虽然有关于ADB-PINACA及其5-氟戊基类似物5F-ADB-PINACA几例严重的中毒病例报道，但它仍然是迄今经测试的最有效的合成大麻素。，根据国家的不同，ADB-PINACA和5F-ADB-PINACA具有不同的法律地位。合成的大麻素代谢物在尿液中占主导地位，使特定代谢物的检测成为临床和法医标本中证明摄入量最可靠的方法。然而，目前还没有关于ADB-PINACA和5F-PINACA代谢的数据。

近日，临床化学杂志（Clinical Chemistry）在线发表了巴尔的摩医学化学与药物代谢科及临床药理学和治疗研究部门关于鉴定两种合成大麻素类似物的研究。

虽然有关于ADB-PINACA及其5-氟戊基类似物5F-ADB-PINACA几例严重的中毒病例报道，但它仍然是迄今经测试的最有效的合成大麻素。，根据国家的不同，ADB-PINACA和5F-ADB-PINACA具有不同的法律地位。合成的大麻素代谢物在尿液中占主导地位，使特定代谢物的检测成为临床和法医标本中证明摄入量最可靠的方法。然而，目前还没有关于ADB-PINACA和5F-PINACA代谢的数据。单个氟原子的取代能够将2个可能共享主要代谢物的分子区分开。对于某些合法应用，区分ADB-PINACA和5F-PINACA摄入量至关重要。为此，我们确定了它们在人体内的代谢。

研究人员将 ADB-PINACA和5F-PINACA在冷冻保存的人肝细胞中孵育3小时，然后进行液相色谱 - 高分辨质谱分析。数据采用Compound Discoverer处理。

研究结果显示分别鉴定了19和12个主要的ADB-PINACA和5F-ADB-PINACA代谢物。主要代谢反应包括戊基羟基化，羟基化，随后氧化（酮形成）和ADB-PINACA的葡糖醛酸化，以及氧化脱氟，然后羧化5F-ADB-PINACA。

研究员认推荐ADB-PINACA酮戊基和羟戊基，ADB-PINACA 5-羟基戊酸和戊酸分别作为ADB-PINACA和5F-ADB-PINACA摄入的最佳标记。由于2种化合物存在位点异构体作为初级代谢产物，因此需要监测独特的产物离子和优化的色谱条件，以明确区分ADB-PINACA和5F-ADB-PINACA摄入。

原始出处：

Jeremy Carlier, Xingxing Diao, Karl B. Scheidweiler,et al.Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry. DOI: 10.1373/clinchem.2016.267575 Published March 2017.

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2017-07-22 lsndxfj

#高分辨#

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2017-06-23 lishizhe

#ACA#

66 0
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2017-08-10 ms8543593053280928

#高分辨率#

69 0
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2018-03-07 xjy02

#肝细胞#

56 0
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2017-03-25 kcb069

#大麻#

62 0
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2017-03-25 zhangj7108

#大麻素#

73 0
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2017-03-25 yangshch

#细胞代谢#

72 0
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2017-03-25 jeanqiuqiu

#质谱#

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CLIN CHEM：利用人体肝细胞代谢和高分辨率质谱区分析合成大麻素ADB-PINACA和5F-ADB-PINACA的摄入

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