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Scand J Gastroenterol:慢乙肝患者肝硬化分期与抗病毒治疗期间发生肝癌的风险

2017-06-27 佚名 国际肝病

韩国首尔庆熙大学医学院Shim等近日完成的一项研究表明,慢性乙型肝炎(CHB)患者在应用恩替卡韦(ETV)抗病毒治疗中,肝硬化伴显着 门静脉高压症(食管胃底静脉曲张或腹水)、饮酒和高龄是发生肝细胞癌(HCC)的独立预测因素。


韩国首尔庆熙大学医学院Shim等近日完成的一项研究表明,慢性乙型肝炎(CHB)患者在应用恩替卡韦(ETV)抗病毒治疗中,肝硬化伴显着 门静脉高压症(食管胃底静脉曲张或腹水)、饮酒和高龄是发生肝细胞癌(HCC)的独立预测因素。

该项回顾性研究总共纳入356例年龄为40~69岁、无HCC史、接受ETV抗病毒治疗≥6个月的CHB初治患者,分别对无肝硬化患者、肝硬化无食管胃底静脉曲张(1期)、肝硬化伴食管胃底静脉曲张(2期)和伴腹水(3期)患者的HCC发生率进行评估,确定患者应用ETV抗病毒治疗期间发生HCC的预测因素。

结果,中数随访时间为3.6年,其中45例(12.6%)患者发生HCC,无肝硬化、肝硬化1期、2期和3期患者的HCC年发生率分别为0.4%、2.6%、9.8%和6.7%。多因素分析表明,2期肝硬化(HR=17.16,P<0.001)、饮酒(HR=3.84,P<0.001)和高龄(HR=1.06,P=0.010)与HCC发生风险显着相关。饮酒患者戒酒2年后的HCC发生风险显着降低(P=0.0314)

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    2018-05-06 许安
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    2017-06-29 yahu
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    2017-06-28 130****4638

    学习了受益匪浅

    0

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