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Stroke:动脉瘤性蛛网膜下腔出血后院内死亡的预测因素!

2018-01-16 xing.T MedSci原创

由此可见,几个因素(其中包含可改变的因素)似乎与动脉瘤性蛛网膜下腔出血后院内死亡有关。 该研究的数据表明旨在降低再出血风险的策略在积极治疗的患者中是最有运用前景的。

近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在确定动脉瘤性蛛网膜下腔出血患者住院期间死亡的预测因素并评估其影响。

研究人员回顾性地分析了全国多中心登记处的瑞士三级神经外科住院的所有动脉瘤性蛛网膜下腔出血病例(动脉瘤性蛛网膜下腔出血的瑞士研究(瑞士SOS) ; 2009-2015)。研究人员确定了院内死亡的临床和影像学独立预测因子,并通过多变量logistic回归计算了校正后的比值比(aOR)来确定其效应大小。同时,使用Kaplan-Meier曲线展示生存曲线。

在瑞士SOS数据库中有1866例动脉瘤性蛛网膜下腔出血患者的数据。院内死亡率为20%(n=373)。在197例(10.6%)积极治疗的患者入院后停止治疗(未发生动脉瘤堵塞),并将该队列排除在主要统计学模型的分析之外。在余下的1669例患者中,院内死亡率为13.9%(n=232)。住院死亡的强烈独立预测因素为再出血(aOR为7.69; 95%可信区间为3.00-19.71; P<0.001)、可归因于迟发性脑缺血的脑梗塞(aOR为3.66; 95%可信区间为1.94-6.89; P<0.001)、脑室内出血(aOR为2.57; 95%可信区间为1.43-4.62; P=0.003)以及治疗后新发梗死(aOR为2.65; 95%可信区间为1.38-5.09; P=0.003) 。

由此可见,几个因素(其中包含可改变的因素)似乎与动脉瘤性蛛网膜下腔出血后院内死亡有关。 该研究的数据表明旨在降低再出血风险的策略在积极治疗的患者中是最有运用前景的。

原始出处:


Martin Nikolaus Stienens,et al. Predictors of In-Hospital Death After Aneurysmal Subarachnoid Hemorrhage Analysis of a Nationwide Database (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]).Stroke. 2018.https://doi.org/10.1161/STROKEAHA.117.019328

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Am J Emerg Med:入院乳酸水平可能预测动脉瘤性蛛网膜下腔出血死亡率

背景:动脉瘤性蛛网膜下腔出血(SAH)是出血性脑卒中的最具破坏性的形式。主要根据初步临床表现预测死亡的发生。初始血清乳酸水平已被证明可以预测死亡和疾病的严重程度。初始血清乳酸可能是一个客观的预测因子或死亡率。方法:回顾性分析一个大型学术中心超过42个月的,动脉瘤性蛛网膜下腔出血的患者。。收集的数据包括人口统计数据,临床数据,血清和临床预后数据。在基线时收集流行病学资料,并对住院病人进行随访。研究者

Stroke:动脉瘤性蛛网膜下腔出血患者额叶激活增强

该研究已经证实在执行任务过程中为取得好的表现,前扣带回和前基底区域激活更加明显,前扣带回激活程度与认知(蒙特利尔认知评价)评分呈负相关。

Stroke:动脉瘤性蛛网膜下腔出血患者使用大麻脑血管风险增加

目前对于动脉瘤性蛛网膜下腔出血(aSAH)患者使用大麻事件,以及其对于发病率,死亡率和结果的影响都是未知的。该研究的目的是评估aSAH患者使用大麻和结果之间的关系。2010年和2015年之间,来自美国德克萨斯大学的研究人员对aSAH连续收治病人的记录进行了审查。尿液药物筛选为阴性的aSAH患者的临床特征及结果与大麻阳性(CB+)的结果进行了比较。回归分析用于评估关联性。该研究组共包括108例患者;

Stroke:早期镁治疗对于动脉瘤性蛛网膜下腔出血没有明显效果(荟萃分析)

迟发性脑缺血(DCI)是动脉瘤性蛛网膜下腔出血(SAH)后预后不良的一个重要原因。症状发作后<4天开始镁治疗的试验发现对于SAH预后不良或DCI没有影响。更早期的治疗可能会更有效,但个别试验没有足够的力量进行这样的亚组分析。研究人员进行了一项个别患者数据的荟萃分析,以研究是否SAH后24小时内不同的时间内给予镁治疗是有效的。患者根据症状发作和研究药物的开始之间进行分类:<6,6至12,

Stroke:动脉瘤性蛛网膜下腔出血(aSAH)后存在超额死亡率

动脉瘤性蛛网膜下腔出血(aSAH)具有非常高的病死率以及降低患者寿命,但与aSAH相关长期幸存患者数据非常缺乏。本文研究人员旨在评估aSAH事件发生后的长期超额死亡率和相关风险因素。 方法:这项顾性随访研究在1980-2007年间在赫尔辛基神经外科进行。在这项研究中,研究人员收纳了aSAH幸存≥1年的患者3078例,随访开始于aSAH后1年并随访至患者死亡或2012年底。使用相匹配的普通人群对死

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