BMC Public Health：纪立农等发现中国2型糖尿病患者达标率低

2013-07-24 BMC Public Health dxy

入组患者基线特征中国成人中2型糖尿病（T2DM）的患病率增长迅速，但现有中国糖尿病管理和血糖控制状况的数据有限。为了评估口服降糖药（OADs）、胰高血糖素样肽-1（GLP-1）受体激动剂和胰岛素在中国多地区T2DM治疗中的疗效。来自北京大学纪立农教授及其团队进行了一项研究（Glycemic control among patients in China with type 2

入组患者基线特征

中国成人中2型糖尿病（T2DM）的患病率增长迅速，但现有中国糖尿病管理和血糖控制状况的数据有限。为了评估口服降糖药（OADs）、胰高血糖素样肽-1（GLP-1）受体激动剂和胰岛素在中国多地区T2DM治疗中的疗效。来自北京大学纪立农教授及其团队进行了一项研究（Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables），该研究发现不到三分之一的患者达到HbA1c＜7.0%的目标。随着糖尿病病程延长，血糖达标率下降和胰岛素使用增加。该研究结果在线发表在2013年6月21日的《BMC公共卫生》（BMC Public Health）杂志上，该杂志影响因子为2.08。

该研究是一项在中国606家医院门诊患者中进行的多中心、横断面调查。在2011年4月至6月期间收集所有患者的数据。

该研究结果表明，共有238639例患者纳入该研究。合格的患者接受单用OADs（157212例[65.88%]）、OADs联合胰岛素（80973例[33.93%]）、或OADs联合GLP-1受体激动剂（454例[0.19%]）治疗。OAD单药治疗组、OAD联合胰岛素组和OAD联合GLP-1受体激动剂组平均糖化血红蛋白（HbA1c）水平（＋/－SD）分别为7.67%(＋/－1.58%)、8.21%(＋/－1.91%)、和7.80%(＋/－1.76%)。三个组中，分别有34.63%、26.21%和36.21%的患者达到HbA1c＜7.0%的目标。平均HbA1c和A1c＜7.0%达标率与T2DM病程有关。

该研究发现，不到三分之一的患者达到HbA1c＜7.0%的目标。随着糖尿病病程延长，血糖达标率下降和胰岛素使用增加。

Ji LN, Lu JM, Guo XH, Yang WY, Weng JP, Jia WP, Zou DJ, Zhou ZG, Yu DM, Liu J, Shan ZY, Yang YZ, Hu RM, Zhu DL, Yang LY, Chen L, Zhao ZG, Li QF, Tian HM, Ji QH, Liu J, Ge JP, Shi LX, Xu YC; Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables; BMC Public Health. 2013 Jun 21;13(1):602.

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2013-09-19 shizhenshan

#ALT#

100 0
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2014-01-21 bshuang

#纪立农#

73 0
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2013-09-26 ms3025846204744509

#BMC#

68 0
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2013-07-26 zhaojie88

#2型糖尿病患者#

97 0
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2013-07-26 xue8604

#糖尿病患者#

89 0
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2013-07-26 yyanpro@28cn.c

#Health#

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BMC Public Health：纪立农等发现中国2型糖尿病患者达标率低

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