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Science: 基因魔剪”有望更快更准

2017-10-05 文姜 生物探索

瑞典Uppsala大学的研究团队在Science上发表了一项新研究,对“基因魔剪”CRISPR-Cas9如何在基因组中搜索特定靶序列的过程进行了揭秘,研究结果有望将这把基因魔剪改进得更快更准。

瑞典Uppsala大学的研究团队在Science上发表了一项新研究,对“基因魔剪”CRISPR-Cas9如何在基因组中搜索特定靶序列的过程进行了揭秘,研究结果有望将这把基因魔剪改进得更快更准。

不到十年,CRISPR-Cas9就已经彻底改变了生物学研究——它让更正或修改任何DNA序列成为可能。这把“基因魔剪”也使遗传病有了治愈和预防的希望。

既然比作一把“剪刀”,当然是越快越好使。而瑞典Uppsala大学的这项最新研究结果,正好可以提高“基因魔剪”的性能,让它使用起来更快、更可靠。

1测量基因魔剪找到靶序列要多久

Cas9令人兴奋的地方是这个分子可以加入人工的基因编码,然后它会在基因组中寻找这个人工编码的相应序列。

大多数搜索DNA密码的蛋白质只能通过检测DNA双螺旋的外部结构来识别一个特定的序列。但Cas9可以搜索任意的代码,在正确的地方它需要打开DNA双螺旋结构和将序列和人工编码进行比较。这项研究的负责人Johan Elf说:“令人难以置信的是,它可以在不使用任何能量的情况下搜索整个基因组。”

研究人员已经开发了两个新的方法来测量Cas9需要多久找到它的靶序列。第一种方法表明,它搜索整个细菌基因组(即通过四百万个碱基对),需要六小时。这个结果也可以通过第二种独立技术加以验证。研究人员通过测量实时Cas9分子标记,所发现的时间也是符合的:Cas9测试每一个位置至少要30毫秒。

2这个过程有望加快

Johan Elf说:“结果表明, Cas9为其灵活性付出的代价是时间。为了更快地找到目标、用更多的Cas9分子寻找同样的DNA序列是必要的”。

为了在一个合理的时间内让Cas9找到正确的序列,可以提高它的浓度。但这会造成细胞中的严重问题,由于搜索过程的机理现在已经被理解,找到了关于系统如何改进的重要线索。通过牺牲Cas9的一部分灵活性,这将有可能设计出医学上可用的基因魔剪,足够编辑各种基因的同时,速度更快。

Elf指出该结果为研究人员们提供了如何实现这种解决方案的线索,其关键是在于 “PAM序列”,这个序列确定在何处以及Cas9打开DNA双螺旋有多频繁。如果让基因魔剪不需要多次打开螺旋以找到目标,不仅速度会更快,还能减少副作用的风险。

原始出处:
Jones DL, Leroy P, Unoson C, et al.Kinetics of dCas9 target search in Escherichia coli.Science. 2017 Sep 29;357(6358):1420-1424. doi: 10.1126/science.aah7084. Epub 2017 Sep 28.

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    2017-10-07 jichang
  3. [GetPortalCommentsPageByObjectIdResponse(id=1683442, encodeId=48ef1683442c6, content=<a href='/topic/show?id=a576102854fe' target=_blank style='color:#2F92EE;'>#魔剪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102854, encryptionId=a576102854fe, topicName=魔剪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c09b27973273, createdName=neurosurgeon, createdTime=Wed Aug 22 00:01:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375701, encodeId=ef8713e570184, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Oct 07 00:01:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250552, encodeId=c14d25055216, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Thu Oct 05 14:54:39 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250521, encodeId=d443250521bc, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Oct 05 10:39:26 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250517, encodeId=5e0525051e3a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 05 10:31:09 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250508, encodeId=3935250508ef, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 05 10:18:35 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250507, encodeId=f2ca25050e1f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27762113155, createdName=小铭的皮普, createdTime=Thu Oct 05 10:10:13 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 hhh678

    henhao

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1683442, encodeId=48ef1683442c6, content=<a href='/topic/show?id=a576102854fe' target=_blank style='color:#2F92EE;'>#魔剪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102854, encryptionId=a576102854fe, topicName=魔剪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c09b27973273, createdName=neurosurgeon, createdTime=Wed Aug 22 00:01:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375701, encodeId=ef8713e570184, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Oct 07 00:01:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250552, encodeId=c14d25055216, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Thu Oct 05 14:54:39 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250521, encodeId=d443250521bc, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Oct 05 10:39:26 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250517, encodeId=5e0525051e3a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 05 10:31:09 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250508, encodeId=3935250508ef, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 05 10:18:35 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250507, encodeId=f2ca25050e1f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27762113155, createdName=小铭的皮普, createdTime=Thu Oct 05 10:10:13 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1683442, encodeId=48ef1683442c6, content=<a href='/topic/show?id=a576102854fe' target=_blank style='color:#2F92EE;'>#魔剪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102854, encryptionId=a576102854fe, topicName=魔剪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c09b27973273, createdName=neurosurgeon, createdTime=Wed Aug 22 00:01:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375701, encodeId=ef8713e570184, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Oct 07 00:01:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250552, encodeId=c14d25055216, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Thu Oct 05 14:54:39 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250521, encodeId=d443250521bc, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Oct 05 10:39:26 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250517, encodeId=5e0525051e3a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 05 10:31:09 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250508, encodeId=3935250508ef, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 05 10:18:35 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250507, encodeId=f2ca25050e1f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27762113155, createdName=小铭的皮普, createdTime=Thu Oct 05 10:10:13 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 刘煜

    谢谢分享学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1683442, encodeId=48ef1683442c6, content=<a href='/topic/show?id=a576102854fe' target=_blank style='color:#2F92EE;'>#魔剪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102854, encryptionId=a576102854fe, topicName=魔剪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c09b27973273, createdName=neurosurgeon, createdTime=Wed Aug 22 00:01:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375701, encodeId=ef8713e570184, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Oct 07 00:01:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250552, encodeId=c14d25055216, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Thu Oct 05 14:54:39 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250521, encodeId=d443250521bc, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Oct 05 10:39:26 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250517, encodeId=5e0525051e3a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 05 10:31:09 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250508, encodeId=3935250508ef, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 05 10:18:35 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250507, encodeId=f2ca25050e1f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27762113155, createdName=小铭的皮普, createdTime=Thu Oct 05 10:10:13 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 龙胆草

    学习谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1683442, encodeId=48ef1683442c6, content=<a href='/topic/show?id=a576102854fe' target=_blank style='color:#2F92EE;'>#魔剪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102854, encryptionId=a576102854fe, topicName=魔剪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c09b27973273, createdName=neurosurgeon, createdTime=Wed Aug 22 00:01:00 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375701, encodeId=ef8713e570184, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sat Oct 07 00:01:00 CST 2017, time=2017-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250552, encodeId=c14d25055216, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Thu Oct 05 14:54:39 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250521, encodeId=d443250521bc, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Oct 05 10:39:26 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250517, encodeId=5e0525051e3a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Thu Oct 05 10:31:09 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250508, encodeId=3935250508ef, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Oct 05 10:18:35 CST 2017, time=2017-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=250507, encodeId=f2ca25050e1f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=27762113155, createdName=小铭的皮普, createdTime=Thu Oct 05 10:10:13 CST 2017, time=2017-10-05, status=1, ipAttribution=)]
    2017-10-05 小铭的皮普

    学习了

    0

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